I just had my first scan after being on Ibrance and Letrozole for almost 5 cycles. Good and bad news. Some tumors had shrunk while others had grown. My doctor is going to change my treatment to the following; Aromasin, Ribociclib which he says are similar to what I have been taking but they are going to add Affinitor which he says is more of a targeted therapy. Really sad about the whole situation as I was handling the Ibrance and letrozole with no real side effects. My doctor still seems optimistic and thankfully is encouraging. He is part of UCLA so I know he is up on all the latest and greatest. Anybody have an experience with these new drugs. I see him next week so not sure exactly when I will start them. I hate this freaking disease!! I know I sound negative and I am a really positive person but just having a pity party right now.