Fred the iron molecules tale : The end

This will only make sense if you’ve read my previous post

healthunlocked.com/rlsuk/po....

There was a question in this post and I promised the writer of the best answer a chocolate muffin.

It’s my opinion that the best information was provided by Ironbrain, so the muffin is for you.

Sorry, I can’t literally send one to you. I have no idea what condition it might be in by the time it reached you.

My simplistic interpretation of what happens to iron when it get’s into the brain in relation to RLS and nothing else is this. (See ironbrains' links below).

Iron is taken into brain cells (neurons) and some of these will be involved with RLS. In these cells some iron is taken up by structures called mitochondria and some iron remains in the liquid that’s found in the cell (cytosol).

The iron in the mitochondria may perform particular functions, whereas the iron outside (cytosol) performs different functions.

The iron outside plays a part in normal dopamine and adenosine function, without which RLS can occur.

Apparently, it has been found that there is both an excess of mitochondria and an excess of iron in the mitochondria in RLS and hence, on balance, insufficient iron outside thus compromising dopamine and adenosine functions.

academic.oup.com/jnen/artic...

Unfortunately, other studies find a lack of mitochondrial iron.

movementdisorders.onlinelib....

MY story has ended, but for me the end of the story of this elusive condition has again eluded me

[Hidden]

I haven't drunk beer in decades so couldn't tell you.

I used to get headaches with beer in my youth, but I think it was the quantity, not the quality.

[Shumbah]

That was awesome reading and helps me understand we my husband can be anaemic and not suffer RLS

Manerva I hope you made that chocolate muffin with Guinness 💪

[Hidden in reply to Shumbah]

OOops, I got it from Google Images, i didn't mention Guinness.

[Shumbah in reply to Hidden]

Back in the day when I had my first 2 babies they would make us stay hospital with the first one for 10 days and we had to drink one big bottle of stout or Guinness with lunch for the iron

Can’t say I was a fan

[Hidden in reply to Shumbah]

There was another popular stout used here called "Mackeson". Not as well known as Guinness.