Lyrica for withdrawals.: This is an... - Restless Legs Syn...

Restless Legs Syndrome

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Lyrica for withdrawals.

Madlegs1 profile image

This is an article about using Pregabalin/ Lyrica for helping with withdrawals (specifically for opiates- but the conditions are similar)

It may be helpful to some. Gabapentin is used by others for similar effects.

Good luck.

8 Replies

This reads more like an advert than an evidence based article. In fact that's what it is.

I haven't yet checked the accuracy of what it says about flight or fight in relation to opiate withdrawal but suspect it's not quite right.

A shame because Pregablin has a known therapeutic effect. Personally if I didn't know that already, I would see this as a scam.

Madlegs1 profile image
Madlegs1 in reply to Manerva

He is very good on methods of coping with withdrawal. You just have to ignore the hard sell.

It was one of the few sites that helped me coming off Fentanyl.

He himself is a recovered addict, and understands what we have to go through.

Manerva profile image
Manerva in reply to Madlegs1

Thanks, that puts a different light on it.


I’m sorry but the whole setup of the article screams advertising. Just saying. The fight or flight response does not come from the central nervous system but the autonomic nervous system, which jumps automatically into a response when we feel threatened by danger. Him saying the fight or flight response is akin to opiate withdrawal symptoms doesn’t really follow either. During fight or flight your body is getting ready to either combat something or someone or flee the situation so it isn’t freaking out (not scientific wording I know 🤓) like it does when you’re in withdrawal where you sweat, get diarrhea, etc. Your body in fight or flight is actually slowing down some of these processes (tightening sphincters for example so no diarrhea, don’t have time for that) so it can appropriately respond. You can’t have your body going haywire during fight or flight or you’re going to get killed or whatever. This just doesn’t fit what he’s saying.

He also states the locus coeruleus is the principal site in the brain for the synthesis of this fight or flight syndrome. That’s not true. * [The reaction begins in the amygdala, which triggers a neural response in the hypothalamus. The initial reaction is followed by activation of the pituitary gland and secretion of the hormone ACTH.[9] The adrenal gland is activated almost simultaneously, via the sympathetic nervous system, and releases the hormone epinephrine. The release of chemical messengers results in the production of the hormone cortisol, which increases blood pressure, blood sugar, and suppresses the immune system.[10] The initial response and subsequent reactions are triggered in an effort to create a boost of energy.

The LC-NA system modulates cortical, subcortical, cerebellar, brainstem, and spinal cord circuits. Some of the most important functions influenced by this system are:[6][7]

-Arousal and sleep-wake cycle

-Attention and memory

-Behavioral flexibility, behavioral inhibition and stress (psychological)

-Cognitive control



-Posture and balance

The locus coeruleus is a part of the reticular activating system, and is almost completely inactivated in rapid eye movement sleep.[8] * The asterisk mark where I borrowed from Wikipedia and then stopped. *This all borrowed from Wikipedia. However if you don’t trust them then any physiology book will say the same.

Also pregabalin (Lyrica) is not yet recognized as an appropriate treatment for withdrawal as stated by this article There are studies currently ongoing that are further testing this but the ones I saw include other drugs to help control the withdrawal symptoms concurrently with the pregabalin. There also needs to be a lot of caution using this for withdrawal as it has itself the possibility of causing addiction in persons with a past problem with addiction, this directly from the handout I get each time from the pharmacy when I get my prescription for fibromyalgia. I’m not saying there is not anecdotal evidence but it is not quite 100% a scientific method for treatment of withdrawal until more studies have corroborated this. Not trying to be a jerk but to put this in a more scientific light.


Thanks for the corrections.

I’m sorry. I still feel like a jerk.


There are no jerks in scientific analysis. Only facts and refutations.

You are an effective refutationist!🤗

Congratulations. 😎

Why thank you very much 🥰. Quite kind of you! I have found everyone here, for the most part 😇, to be very kind and most helpful. I mean I found my doctor thanks to a lovely person on here. You don’t find that level of acceptance and giving out in the “real” world. So, I just want to thank you madlegs1! I’m trying to learn everyone’s journey but that is much easier said than done. Everyone’s is so incredibly different. Anyway,it’s very nice to have a place to go where if you say you wandered the house all night because your legs wouldn’t let you sit down people don’t think you’re exaggerating because often they’ve been there themselves. So glad I stumbled upon you all and thanks to warmly welcoming us yanks from yonder country and just because “certain people “ feel certain ways you can know we the people don’t.


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