Which drugs make RLS worse? - Restless Legs Syn...

Restless Legs Syndrome

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Which drugs make RLS worse?

Noddedoffagain profile image
11 Replies

I am seeing a consultant at a sleep clinic on Wednesday 30th January. Last time she wanted to prescribe me Amitriptyline. I knew that I had seen that this drug made RLS worse and told her so. She actually researched it herself & rang me at home to tell me not to take it.

So that I can prepare for my visit does anyone know if there is a list of drugs that make RLS worse

Many thanks for this amazing, supportive site & all the knowledge that is shared

11 Replies
Kaarina profile image

This link contains a section on medications to avoid: rls-uk.org/treatment/ Hope that is of some help.

May I suggest you also take with you information about what does work for RLS as your consultant clearly knows very little if she prescribed amitripyline!

LotteM profile image

A very comprehensive overview and discussion of medicines is also available on rlshelp.org. Treatment page.

Noddedoffagain profile image

Thank you for that information & I certainly will take what does work with me as well as what does not. I have actually learnt so much from this site that it gave me confidence to challenge her. Again, thank you all


I just wanted to add that I have been on Amitriptyline 50mg for around 12 months and I have not had a problem with it.

Noddedoffagain profile image

It’s a really weird syndrome - thank you cdtofi

craigm1114 profile image

Long term no-nos mirapex, requip, generics are pramipexole and ropinerole. They are guaranteed to set up augmentation. Good luck.

Noddedoffagain profile image

Thanks craigm1114. I augmented 18 months ago having been on Mirapex for 12 years. After being given a variety of other drugs all of which gave me horrible hives I am now using a 1mg Neupro patch. I usually sleep for 2hours from 5am to 7am. If I’m lucky a good night will mean an hour or so - get up for an hour - then maybe an hour back in bed and so on..... I really don’t know what to do next as I don’t want to increase the patch only to have to face augmentation again. Tweeked my diet and eat my main meal at lunchtime. This seems to help a little

I go to see the consultant this afternoon so fingers crossed that I get some help.

Coonj profile image

How are you doing?

Noddedoffagain profile image

Not a wink of sleep last night and still trying to get some help. Between my hair looking like a lions mane 🦁and my droopy eyes through lack of sleep 💤 it’s just as well we are locked down. Thank you for asking - it is really appreciated x

No_One_ profile image

I have to avoid anything with sugar 6 hours before going to bed. I take Requip and hate that stuff. It takes 2-3 hours to kick in and doesn't do me any favors the next day.

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