Is Gabapentin worth it?!: Hi, I’ve now... - Restless Legs Syn...

Restless Legs Syndrome

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Is Gabapentin worth it?!

Lapsedrunner profile image
15 Replies

Hi,

I’ve now been off pramipexole for just over 2 weeks and have been taking 200mgGabapentin for just over 4 weeks.

Sleep isn’t brilliant, I spend time awake and wriggly around 4 times during the night, but no evening augmentation symptoms now.

I know I am on a low dose of Gabapentin but it seems to have wrecked my sexual response unless it is a huge coincidence!

My plan is to come off it to see if it’s doing anything for my RLS and to see if my sexual response recovers!

How slowly do I need to do this?

Thanks so much in advance!

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Lapsedrunner
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15 Replies
Madlegs1 profile image
Madlegs1

Depending on how much Prami and for how long you were taking it, you will still be suffering withdrawal symptoms.

The Gaba won't help with that.

As you say , you are on a low dose (could go up to 900 pd if tolerated).

I'm not sure about the sexual function, but is it mentioned on the patient leaflet?

It's always worth testing just how much rls we are suffering in a " naked" environment. But be sure about all the possible triggers that may be in your life.

All written about here too many times to repeat.

Good luck.

Damnitall profile image
Damnitall in reply to Madlegs1

GABApentin slows nerve response down all over for my neuropathy. That’s why it’s brand Neurontin is used to pass lie detector tests. I take 800mg three times a day as I tried to decrease it but foot neuropathy went wild and I could not tolerate it. Not entirely effective but I need sexual response. Wellbutrin is the only antidepressant that does not affect sexual response so I take 300 XL down from 450 XL. I take 15mg of Adderall twice per day for ADD and Narcolepsy. Neuvigil is better than Provigil for Narcolepsy. Brand Names rather than generics can make a difference. An extra GABA and clonazapam in the middle of the night shuts down RLS/DLS along with early Adderall (NOT EXTRA, early). I still need something more than GABA.

Damnitall profile image
Damnitall in reply to Damnitall

I quit Lyrica due to lack of sexual response similar to antidepressants

rls_optimist profile image
rls_optimist in reply to Madlegs1

Hi, Madlegs, where did you read that 900 mg is the max for gabapentin? I believe it's more like 2400 mg. There are many of us here and elsewhere who take much more than 900, including myself (1800), with no problem. (Not everyone, of course: some have more side effects than others.)

Madlegs1 profile image
Madlegs1 in reply to rls_optimist

That is Dr Buchfuhrers advice- strictly for rls.

The max dose of 2400 relates to nueropathic disorders and often gives rise to severe side effects.

He reckons there is no extra advantage in going above 900 for rls.

You can check him out on

rlshelp.org

Cheers.

rls_optimist profile image
rls_optimist in reply to Madlegs1

Well, here's what I see on his RLS/PLMD Treatment Page on that site, under the Neurontin (gabapentin) section:

"The dose of Neurontin varies from 300-2000 mg per day, with the average dose being 800-900 mg. Neurontin should be started one 300 mg capsule at bedtime. Another 300 mg capsule can be added as needed every few days. The usual bedtime dose is between 300-800 mg. For severe RLS, a morning and afternoon dose can be added. Neurontin comes in 100 mg, 300 mg and 400 mg capsules.

In our experience, the response to Neurontin can be quite variable, but many RLS patients have achieved benefit from this drug with minimal side effects. The effectiveness of this medication often diminishes after 1-2 years. In one study, the average dose of Neurontin needed was about 1800 mg per day."

I know that he sometimes recommends pregabalin over gabapentin because it's better absorbed. But I also know that different people get better or worse side effects from one vs. the other. For myself, I had some rather serious balance issues on pregabalin (feeling like I was about to fall from time to time, had to catch myself) as well as morning blurry vision. I get much milder side effects from gabapentin, and no balance issues. I can live with the limited absorption, as it's equally effective for me as pregabalin was as long as I keep the dose around 1800 mg.

bvlgari profile image
bvlgari

Couldn't tolerate gabapentin side effects were awful. If it's for restless legs have you tried ropinerole, I've been on them for 6 years and can't be without them.

Joolsg profile image
Joolsg in reply to bvlgari

The person posting was on pramipexole and came off it because of Augmentation. Ropinirole is another dopamine agonist so would cause Augmentation very quickly. Best avoided.

bvlgari profile image
bvlgari in reply to Joolsg

Sorry only trying to help.

Joolsg profile image
Joolsg in reply to bvlgari

I realise that bvlgari. I’m delighted Ropinirole is still working for you. It worked fine for me for 10 years and then I had to keep increasing the dose. Then I couldn’t sit still in the early evening and it moved to my arms and became so intense I couldn’t bear it.

Just be careful not to increase your dose and keep a watch for any signs of Augmentation.

Long may it help you.

bvlgari profile image
bvlgari in reply to Joolsg

What are you taking now just in case I start getting augmentation

Joolsg profile image
Joolsg in reply to bvlgari

I’m now on Pregabalin 100-150mg and 25mg of OxyContin per day.

It works 80% of the time- but I no longer get RLS sitting in a car or the cinema. I can get back to sleep quickly after a few leg stretches.

Hopefully Ropinirole will keep working for you for many years.

Jools

bvlgari profile image
bvlgari in reply to Joolsg

That's interesting I'm on low dose oxycoontin for fibromyalgia wonder if that's helping as I haven't increased my ropinerole still on 1mg twice a day. Thanks

Joolsg profile image
Joolsg in reply to bvlgari

It will definitely be helping your RLS. It would also explain why you haven’t needed to increase dose of Ropinirole.

Lapsedrunner profile image
Lapsedrunner

Update on this...I think it was more about DA withdrawal...5 weeks off Pramipexole things are working better 😉

Also 100g Gabapentin seems to have started to help me sleep better..2 pretty good nights running!

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