I don't know what to attribute to RA or if symptoms could be something else. This all came on like a landslide; so quickly that my head is still spinning! Are you aware of any muscle pains associated with the plaquenil? Last night standing in line and had weird sensation almost like a tight muscle, pulling from just below groin to just bbelow knee on left leg.. turned into almost achy and dull. Got out of bed this morning and feel same tightness below my right knee. I don't know what to take seriously or what to ignore!