I'm new to this group. I have a anti-ccp of 144 and x-ray shows erosion which is what put my rheumy over the top despite zero inflammatory markers ... although I did have high platelets. She put me on Plaquenil which I've been on for almost three months. I hate to say it, but I feel like I'm getting worse. It scares me because it seems to be happening so fast. I'm still able to be pretty active (work in my garden, walk, etc.) but the pain I deal with in the evening, morning is daily and most especially when the weather changes. I now have to sleep on my back at all times. If I lay on my side, even with a pillow in between my knees, I get terrible knee and hip pain. It's all very scary. I'm fortunate that she gave me hydrocodone which helps me through the bad days, but I'm terrified she's not going to renew my prescription. I get scared that maybe it's the Plaquenil because it only really started getting worse once I was diagnosed. So torn over what to do.