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Meds 4 Anesthetic isoflurane has been shown to promote Alzheimer’s disease (AD) neuropathogenesis

I won't be posting this article unless asked. It is a very heavy clinical read (statistics experimental model etc - Way above my reading age) of tests done on mice only.

You might want to read my summary at the bottom first!

Anesthetic Isoflurane Increases Phosphorylated Tau Levels Mediated by Caspase Activation and Ab


Yuanlin Dong, Xu Wu, Zhipeng Xu, Yiying hang, Zhongcong Xie

From: Geriatric Anesthesia Research Unit, Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital

No year given.



Anesthetic isoflurane has been shown to promote Alzheimer’s disease (AD) neuropathogenesis by inducing caspase

activation and accumulation of b-amyloid (Ab). Phosphorylation of tau protein is another important feature of AD

neuropathogenesis. However, the effects of isoflurane on phosphorylated tau levels remain largely to be determined. We

therefore set out to determine whether isoflurane can increase phosphorylated tau levels. 5 to 8 month-old wild-type and

AD transgenic mice [B6.Cg-Tg (APPswe, PSEN1dE9)85Dbo/J] were treated with 1.4% isoflurane for two hours. The mice brain

tissues were harvested at six, 12 and 24 hours after the anesthesia. For the in vitro studies, primary neurons from wild-type

and the AD transgenic mice were exposed to 2% isoflurane for six hours, and were harvested at the end of anesthesia. The

harvested brain tissues and neurons were subjected to Western blot analysis by which the levels of phosphorylated tau

protein at Serine 262 (Tau-PS262) were determined. Here we show that the isoflurane anesthesia increased Tau-PS262 levels

in brain tissues and primary neurons from the wild-type and AD transgenic mice. Moreover, the isoflurane anesthesia may

induce a greater increase in Tau-PS262 levels in primary neurons and brain tissues from the AD transgenic mice. Finally,

caspase activation inhibitor Z-VAD and Ab generation inhibitor L-685,458 attenuated the isoflurane-induced increases in

Tau-PS262 levels. In conclusion, clinically relevant isoflurane anesthesia increases phosphorylated tau levels, which may

result from the isoflurane-induced caspase activation and Ab generation. These findings will promote more studies to

determine the effects of anesthetics on tau phosphorylation.

My summary: It does increase the Tau levels which are problematic (?causal) with PSP. It does not show if the increase would be significant for someone with PSP. Nor does it show whether those elevated levels remain after its use.

If you are a mouse suffering from PSP please message me and I will send the article to you ;)

Thanks to *** for sending me this... It does suggest best avoid if one can.

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🐭 Thanks



Hind site the Post Meds 7 is far more useful than this study as it is based on humans and has more information.

This one can be ignored - Sorry.