DHEA and Pregnenolone: A recent visit... - Prostate Cancer N...

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DHEA and Pregnenolone

lewicki profile image
19 Replies

A recent visit to a MD in general practice who was interested in administering injections of Testosterone decided to wait and prescribed DHEA and Pregnenolone and MSM instead. His blood test did show these to be low. Also, in this blood test it showed the hormon estrogen to be low.

I am not sure I want to take these as it may wake up my cancer. PSA is <0.04 and T is 10. Only taking Tamsulosin and Dutasteride now for 18 months. No ADT.

Are these supplements a bad idea?

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lewicki profile image
lewicki
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19 Replies

Well Sir? Personally, I won’t risk it . But ,that’s just me . 7 yrs on adt with 3 t. I fear the APC eating me up more than sarcopenia , osteopenia and the rest of my woes . Good luck .✌️🍀

lewicki profile image
lewicki in reply to

Thanks. Always something to decide with this demon.

in reply to lewicki

Decisions ,decisions . Dammed if we do? 😎✌️

I saw a post on here somewhere from someone saying it increased their T. So I tried it after Tulsa-Pro. My Tulsa-Pro did not seem to "get it all" since my PSA only went down from 9 to 2.4 The month after trying those two exact supplements, my PSA went from 2.9 to 6.5. Since then I have had radiation, so I don't know if now it would have the same effect or not and am undetectable. Point being, I don't think its a T workaround as far as cancer goes.

lewicki profile image
lewicki in reply to

Thanks. I am thinking the same.

in reply to lewicki

General consensus seems to be go high T BAT or stay on the porch.

lewicki profile image
lewicki in reply to

No porch for me. I have been to Germany four times for AC-225 and LU-177 . No ADT for 18 months T is <10 and PSA is <0.04. Just trying to get ready when PSA raises and what to do then.

lokibear0803 profile image
lokibear0803

After becoming seriously ill with some kind of influenza, many winters ago, my doctor put me on DHEA + pregnenolone to get me up and running again.

Remarkably, I ran the fastest half-marathon of my life that October…

Distressingly, I was diagnosed with prostate cancer the following January…

My subsequent research revealed that PSA + T should be monitored frequently when taking this combo. I wish my (naturopathic) doctor realized that.

lewicki profile image
lewicki in reply to lokibear0803

Yes it seems the doctors that we trust so much to make uneducated opinions of a serious matter without much concern is not cool.

lokibear0803 profile image
lokibear0803 in reply to lewicki

…it’s safe to say I’ve changed doctors….

Alexandr1 profile image
Alexandr1

My suggestion is to Google Dr. Abraham Morgentaler who has researched the subject of Testosterone supplemtation and Prostate Cancer for more than twenty years. I am both a PC survivor and user of testosterone, a decision initially recommended by my Dr., a leading PC surgeon at a teaching hospital…

lewicki profile image
lewicki in reply to Alexandr1

Thanks for your reply. Do you do what is called BAT which includes ADT or do you do straight T ?

Alexandr1 profile image
Alexandr1

Just Androgel gel…been using ever since Tulsa Pro.

lewicki profile image
lewicki in reply to Alexandr1

That's great. Good news . What is the dosage and time frame. Thanks

Alexandr1 profile image
Alexandr1

Sorry, not on this Forum much. I take 2 pumps at 1,5 mg of solution one to two times a day. Check my T level with every PSA, to make sure I am in “mid range” on T. One of these days I will post a new thread on what I have learned regarding prostate cancer and testosterone. I was given the OK to continue to use T by one of our country’s top PC docs, at a teaching hospital. When he retired, his successor (again a PC specialist) said the same, “continue, no correlation or causal relationship”. Since then my Primary care doc has said the same, as has my “boutique” doc (where I get my annual, pretty intense, physical). For some of the science behind this change regarding T and PC, go to the National Center for Biotechnology Information (NCBI), website, and search for “testosterone” and “prostate cancer”. Lots of relatively recent studies suggesting folks like me who have had or are at risk of having PC have really no reason to avoid testosterone. Many doctors , perhaps due to the to commitment of their patient caseloads, are still relying on how they were trained years ago, rather than on the newer (compelling to me) data which is easily available….

lewicki profile image
lewicki in reply to Alexandr1

Thanks for the reply. I am going to start a program of T with my ONCO. What level of T is mid range? Quite a bit of reading on recommended site. Takes away my fears of doing this. Hope all is well with you.

Alexandr1 profile image
Alexandr1

I try to keep it around 600. Before supplementation for whatever reason (going back perhaps 15 years ago) I was at a baseline of 50….T has made a huge difference in my life, not promoting or advocating, just telling my personal story, based on that first doctor’s advice, as well as lots of subsequent research.

pjoshea13 profile image
pjoshea13

I'm concerned that your estrogen may be too low for bone health. In general, an estradiol [E2] level below 12 pg/mL means bone loss will occur. If so, you need to be on something, IMO, even if it is only a low-dose E2 patch.

DHEA status is usually determined be testing DHEA-sulfate [DHEA-S], which acts as a DHEA reservoir.

DHEA may convert to androstenedione, which may convert to estrone or testosterone [T]. Or to androstenediol, whcich can convert to T. T itself can be converted to E2.

Oddly, we have a ton of DHEA-S when young, but that drops off dramatically as we age. Which is why many healthy men use supplemental DHEA. The usual warning is that one never knows the biological fate of DHEA. I think that the body knows what to do with it. If you use DHEA. I suspect that your T will remain sub-optimal and your E2 will rise above 12 pg/mL, but not above 30 pg/mL. I would monitor the E2:T ratio, though.

Pregnenolone is a DHEA precursor.

Best, -Patrick

lewicki profile image
lewicki in reply to pjoshea13

Recent test my Estradiol ,ultrasensitive, LC/MS is 4 You are right. I am almost 4 inches shorter than I was when I was 25.

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