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Pregnenolone
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Androstenedione & Frailty
In the steroidogenesis cascade, andro can be produced from progesterone, or from
pregnenolone
-->DHEA. As such, production is inhibited by Abiraterone (which targets the enzyme that acts on progesterone and
pregnenolone
.)
In the steroidogenesis cascade, andro can be produced from progesterone, or from
pregnenolone
-->DHEA. As such, production is inhibited by Abiraterone (which targets the enzyme that acts on progesterone and
pregnenolone
.)
pca2004
in
Fight Prostate Cancer
5 months ago
iron test results help please
I’m on 2 grains of NDT and I also take Q10, B12, vit d, vit c, magnesium, selenium, HCL with betaine,
pregnenolone
and a probiotic - no idea if any of these would affect my iron levels??
I’m on 2 grains of NDT and I also take Q10, B12, vit d, vit c, magnesium, selenium, HCL with betaine,
pregnenolone
and a probiotic - no idea if any of these would affect my iron levels??
Mazes
in
Thyroid UK
8 months ago
Pregnenolone
hi everyone I just wondered if there was anyone taking
Pregnenolone
and to hear your experiences with it?
hi everyone I just wondered if there was anyone taking
Pregnenolone
and to hear your experiences with it?
Supermisshelen
in
Thyroid UK
1 year ago
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Insomnia? Some good results here
Tried various HRT's, BHRT creams, NHS Patches, now on
pregnenolone
25mg and have been for 4 weeks. Apart from sore breasts Insomnia continued. I tried adding another 12.5mg of levo and I got horrible hyper feelings despite having some hypo symptoms too.
Tried various HRT's, BHRT creams, NHS Patches, now on
pregnenolone
25mg and have been for 4 weeks. Apart from sore breasts Insomnia continued. I tried adding another 12.5mg of levo and I got horrible hyper feelings despite having some hypo symptoms too.
dayoff
in
Thyroid UK
1 year ago
The possible beneficial effect for the treatment of peripheral neuropathy of two neuroactive steroids, progesterone and pregnenolone
I was researching
pregnenolone
on the internet and came across this article. It may be of interest to anyone struggling with neuropathy.
Pregnenolone
is formed from cholesterol and is the precursor substance for numerous important endogenous hormones.
I was researching
pregnenolone
on the internet and came across this article. It may be of interest to anyone struggling with neuropathy.
Pregnenolone
is formed from cholesterol and is the precursor substance for numerous important endogenous hormones.
Lunario
in
Pernicious Anaemia Society
1 year ago
Dhea and Pregnenolone
My alternative MD wants me to take these. Has anyone done so and will it be a good idea or a bad idea?
My alternative MD wants me to take these. Has anyone done so and will it be a good idea or a bad idea?
lewicki
in
Advanced Prostate Cancer
2 years ago
Slightly confused...
I went back to the book, re-read it, & bought
Pregnenolone
, Adrenavive 1 and Metavive 1 from Dr Myhills site. I now feel good. Not 100% yet, but better even than I did for the 3 weeks the T3 dose was effective. And I read all the clinical reviews that said it was all just mumbo-jumbo rubbish.
I went back to the book, re-read it, & bought
Pregnenolone
, Adrenavive 1 and Metavive 1 from Dr Myhills site. I now feel good. Not 100% yet, but better even than I did for the 3 weeks the T3 dose was effective. And I read all the clinical reviews that said it was all just mumbo-jumbo rubbish.
Ozziemum
in
Thyroid UK
1 year ago
DHEA or PREGNENOLONE?
So my question is, would
Pregnenolone
be a better choice than DHEA? I have an appointment my a menopause specialist in a week and with my Endo in 3 weeks. Thank you
So my question is, would
Pregnenolone
be a better choice than DHEA? I have an appointment my a menopause specialist in a week and with my Endo in 3 weeks. Thank you
PixieElv
in
Thyroid UK
1 year ago
Help needed with these counts and Antibodies
and
Pregnenolone
or low dose hydrocortisone until thyroid levels are up.
and
Pregnenolone
or low dose hydrocortisone until thyroid levels are up.
ainslie
in
Thyroid UK
2 years ago
Adrenal deficiency?
When I think back now, I realise I had these feelings for quite a few weeks, if not longer before starting the job I am taking 1 x
pregnenolone
a day and 6 Soleray adrenal caps per day, which I have been doing for a number of years.
When I think back now, I realise I had these feelings for quite a few weeks, if not longer before starting the job I am taking 1 x
pregnenolone
a day and 6 Soleray adrenal caps per day, which I have been doing for a number of years.
health2015
in
Thyroid UK
2 years ago
DHEA and Pregnenolone
A recent visit to a MD in general practice who was interested in administering injections of Testosterone decided to wait and prescribed DHEA and
Pregnenolone
and MSM instead. His blood test did show these to be low. Also, in this blood test it showed the hormon estrogen to be low.
A recent visit to a MD in general practice who was interested in administering injections of Testosterone decided to wait and prescribed DHEA and
Pregnenolone
and MSM instead. His blood test did show these to be low. Also, in this blood test it showed the hormon estrogen to be low.
lewicki
in
Prostate Cancer Network
2 years ago
High intratumoral dihydrotestosterone is associated with antiandrogen resistance in VCaP prostate cancer xenografts in castrated mice
The CYP17A1 enzyme acts upon
pregnenolone
and progesterone to produce downstream hormones that include androgens.
The CYP17A1 enzyme acts upon
pregnenolone
and progesterone to produce downstream hormones that include androgens.
pjoshea13
in
Advanced Prostate Cancer
2 years ago
Progesterone Receptor.
This presumable leads to higher than normal levels of
pregnenolone
& progesterone. Does that matter? The new study claims that progesterone is indeed bad for PCa patients. "To inhibit the conversion of
pregnenolone
to progesterone, steroidogenic enzyme 3βHSD1 is a promising target ...
This presumable leads to higher than normal levels of
pregnenolone
& progesterone. Does that matter? The new study claims that progesterone is indeed bad for PCa patients. "To inhibit the conversion of
pregnenolone
to progesterone, steroidogenic enzyme 3βHSD1 is a promising target ...
pjoshea13
in
Advanced Prostate Cancer
2 years ago
Pregnenolone
In the following link, Dr Myhill recommends for the treatment of osteoporosis "
pregnenolone
50mgs sublingually daily.
In the following link, Dr Myhill recommends for the treatment of osteoporosis "
pregnenolone
50mgs sublingually daily.
June25
in
Bone Health and Osteoporosis UK
2 years ago
Lab tests - vitamins & minerals
Iodine 45 (range 52-109 mcg/L) Vitamin B6 52.5 (range 2.1-21.7 ng/mL) Vitamin B12 >2000 (range 200-1100 pg/mL) Zinc 72 (range 60-130 mcg/dL) Folate 566 (range >280 mg/mL) Thyroid Peroxidase antibodies 25 (range > IU/mL9)
Pregnenolone
110 (range 22-237 ng/dL) HS CRP 0.5 (range optimal <
Iodine 45 (range 52-109 mcg/L) Vitamin B6 52.5 (range 2.1-21.7 ng/mL) Vitamin B12 >2000 (range 200-1100 pg/mL) Zinc 72 (range 60-130 mcg/dL) Folate 566 (range >280 mg/mL) Thyroid Peroxidase antibodies 25 (range > IU/mL9)
Pregnenolone
110 (range 22-237 ng/dL) HS CRP 0.5 (range optimal <
Xheila
in
Thyroid UK
2 years ago
Pregnenolone and Iron infusion for low RBC and Iron count.
Recent blood test indicated very low
pregnenolone
and Iron.
Pregnenolone
is a pre curser to testosterone and may be a bad idea to supplement. RBC also quite low and was advised to do Iron infusion as iron supplements do not work for an 80 year old. Has anyone dealt with this ? Thanks
Recent blood test indicated very low
pregnenolone
and Iron.
Pregnenolone
is a pre curser to testosterone and may be a bad idea to supplement. RBC also quite low and was advised to do Iron infusion as iron supplements do not work for an 80 year old. Has anyone dealt with this ? Thanks
totom
in
Advanced Prostate Cancer
2 years ago
Functional medicine advice is going in circles
But again reiterated we can definitely help you, I think we'd start with DHEA, I told her at that point that I've already tried DHEA and
Pregnenolone
and that they both make me even more sedated, presumably because they convert to oestrogen and that makes me feel hypo.
But again reiterated we can definitely help you, I think we'd start with DHEA, I told her at that point that I've already tried DHEA and
Pregnenolone
and that they both make me even more sedated, presumably because they convert to oestrogen and that makes me feel hypo.
Jamima
in
Thyroid UK
2 years ago
Androgen Receptor [AR] Axis Therapies
Abiraterone targets all hormones south of progesterone &
pregnenolone
. As Abi & Enzalutamide emerged, with others in the pipeline, Dr. Myers seemed visible excited at the prospect of having so many options after years of nothing new.
Abiraterone targets all hormones south of progesterone &
pregnenolone
. As Abi & Enzalutamide emerged, with others in the pipeline, Dr. Myers seemed visible excited at the prospect of having so many options after years of nothing new.
pjoshea13
in
Advanced Prostate Cancer
2 years ago
Enzalutamide versus Abiraterone Acetate/Prednisone
Abiraterone works via a scorched-earth attack on all hormones in the steroid cascade below progesterone &
pregnenolone
, whereas Enzalutamide is a direct androgen receptor antagonist. In the distant past, many prefered Bicalutamide [Casodex] monotherapy to ADT.
Abiraterone works via a scorched-earth attack on all hormones in the steroid cascade below progesterone &
pregnenolone
, whereas Enzalutamide is a direct androgen receptor antagonist. In the distant past, many prefered Bicalutamide [Casodex] monotherapy to ADT.
pjoshea13
in
Advanced Prostate Cancer
3 years ago
Statins and adrenal androgen levels in prostate cancer: A new twist
Using MS they find no change in serum T or DHT in the statin-treated arm, a borderline significant decrease in canonical adrenal products (
pregnenolone
, 17-OH
pregnenolone
, DHEA, androstenedione (AED); 0.05 < p < 0.10) that was lost after controlling for false discovery, and a significant 35% decrease
Using MS they find no change in serum T or DHT in the statin-treated arm, a borderline significant decrease in canonical adrenal products (
pregnenolone
, 17-OH
pregnenolone
, DHEA, androstenedione (AED); 0.05 < p < 0.10) that was lost after controlling for false discovery, and a significant 35% decrease
pjoshea13
in
Advanced Prostate Cancer
3 years ago
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