Prednisone /prednisolone

[Opename]

Hello guys and girls, quick question there is any difference between prednisone and prednisolone? Jesus Christ God be with us !Christ is Risen!

[HeronNS]

Prednisone is metabolised by the liver into prednisolone. In terms of dosage there is no difference.

[Opename in reply to HeronNS]

There be no problem for me to go from prednisone to prednisolone?

[HeronNS in reply to Opename]

Don't see why there would be? Are you moving?

[Opename in reply to HeronNS]

Yes

[HeronNS in reply to Opename]

If anything the prednisolone is probably slightly better because it's all ready to go, doesn't need the liver to process it first!

[Opename in reply to HeronNS]

There are different adverse effects ?

[HeronNS in reply to Opename]

No, I think everything else is pretty much the same. Just that when you take prednisolone there's one less step for your body to have to take. In the end we are all using prenisolone, because that's what the liver turns our prednisone into.

[Opename in reply to HeronNS]

Thank you for your time ,God Jesus Christ be in your heart !

[HeronNS in reply to Opename]

Hey, we're all in this together! Hope your move goes well and your pred journey continues well, too.

[PMRpro Ambassador in reply to Opename]

There may be - I had no problems with prednisolone and now none with prednisone. Inbetween I was on methyl prednisoone - that I found awful! But even different brands of the same substance can cause different side effects in the same person.

[galp in reply to PMRpro]

I know this is old but relevant to me.

Iwas switched from prednisone to methyl pred.

I thought I was crazy, because it is awful..

Affected my bp and heart rate, and gi .

Starting with a new rheumi..

Been on for 3.5 years. started with Pmr. got pred down to 2 then hit with lung sarcoidosis

things resolved pretty well on 20 the decreases were difficult

Saw Sarcoid spec. who felt I had pred toxicity and we came down, switching to methly pred

Now at two, feeling like PMR symptoms back and but if go up to 4 all other neg things I mentioned above.

return.

She is impossible to get ahold of , tells me to call but never calls back, so I am by the recommendation going to new Dr, though it will be telephonic so thinking that will be tough with my complicated hx.

There are days I wonder if this is an adrenal issue...thoughts?

[PMRpro Ambassador in reply to galp]

I'd love an explanation as to why someone with pred toxicity would do better on methyl pred.

[mepoly20]

As far as I know it is very much the same

[whitefishbay]

Prednisilone is what you get in the UK and prednisone is what you get in the USA. I could be wrong. Often am.

[Hidden in reply to whitefishbay]

You are correct, the difference is the Prednisone has to be processed through the liver before it turns into Prednisolone.

[janmark43]

Only prednisolone is prescribed in the UK and has been for years. Where are you?

[Opename in reply to janmark43]

UK but with private prescription I can use prednison

[galp in reply to janmark43]

Hi

USA

Illinois

She dropped the dosage fast, and it's what she uses ..