Spacing the medication!!!: I've been reading about... - PMRGCAuk

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Spacing the medication!!!

altywhite profile image
46 Replies

I've been reading about not taking Vit D3 and Calcium at the same time as pred, taking it with something fatty..breaking the Adcal tablets in half!! Someone said we needed a spreadsheet for all this medication and I'm thinking that's a good idea!! I'm currently splitting my pred which makes it more complicated!!

I'm also on Levothyroxine and it states on the Adcal patient sheet that 4 hours should be left after taking the thyroxine before taking the Adcal!!

So....currently....Levothyroxine, Omeprazole and Vit K2 on waking!! First dose of pred with breakfast. Adcal about lunchtime. This is where it gets difficult...I was taking my 2nd pred with my evening meal and Adcal at bedtime....but have been going to bed early as I am so tired at the mo (not sleeping well either) so the evening doses are close together.

It's a minefield!!!!

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altywhite profile image
altywhite
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46 Replies
SusyTe profile image
SusyTe

Hi Alty. I take my Calcium/D3 at the same time as my Pred - didn't realise I shouldn't be doing that. What with the HRT patches having to be changed twice a week, the Pred every day, the Metho on a Tuesday and the Folate on a Wednesday, the K2, the B12, and the blood tests, I am struggling to keep on track too - brain fog doesn't help!

Rose1bud profile image
Rose1bud in reply to SusyTe

Bit d I take mine in the evening with a plain yogurt it says take one daily So that could mean mor or evening

Rugger profile image
Rugger

Is it any wonder we forget to put the meat in the oven?!

SusyTe profile image
SusyTe in reply to Rugger

Or walk around looking for my glasses when they are on my head?!

Mrsd12f profile image
Mrsd12f in reply to Rugger

I spent half an hour, last week, looking for my phone, whilst listening to a podcast on the same phone. (The phone was in my pocket and I was listening through headphones!)

DorsetLady profile image
DorsetLadyPMRGCAuk volunteer in reply to Mrsd12f

Love it❤️!

Nap1 profile image
Nap1 in reply to Mrsd12f

That's really hilarious.

SusyTe profile image
SusyTe in reply to Mrsd12f

Glad it's not just me. I have even been searching in my bag for my tube ticket as I have approached the exit, then realised I am actually holding it in my teeth!! Arrrggh!

altywhite profile image
altywhite in reply to Rugger

:) :)

DorsetLady profile image
DorsetLadyPMRGCAuk volunteer

Hi,

Can you swap the evening Pred and Adcal around? I know it's says Pred best taken with food, but a spoonful of yoghurt or glass of milk would probably suffice.

Why are you breaking Adcal tablet in half?

altywhite profile image
altywhite in reply to DorsetLady

Hi DL, I'm not breaking them in half...yet!! haha! I read on another post that we only absorb so much calcium at a time so that person was breaking the tablets in half!! I've not gone down that route! I've always taken the pred with food...never tried milk....or the yoghurt...that sounds even better to me. Thank you. :)

PMRpro profile image
PMRproAmbassador in reply to altywhite

Depends on the tablet - one version is 1000mg calcium which is more than the body will absorb at one time. No doubt there are doctors who don't know that who think it is cost saving...

Though some of them say 1500mg calcium carbonate - which is 600mg elemental calcium which is just about OK. Absorption is highest from doses not more than 500mg - so trumpeting your once-a-day tablet improving compliance isn't really very clever is it?

Admiral06 profile image
Admiral06

Altywhite, The recommended daily allowance (RDA) of calcium for an adult, published by the Food and Nutrition Board (FNB) at the Institute of Medicine of the National Academies, is 1000–1200 mg (1200 mg for age 70 and older) and based on the latest research, it is best to get as much calcium as possible from natural food sources while minimizing supplemental calcium - especially calcium carbonate. Interestingly, the number the RDA is based on, (the number that really matters), is how much calcium you absorb, not how much you eat. The average adult needs 300-400 mg of calcium that can be readily metabolized and used to satisfy the body’s calcium requirements.

The following is the very short list of high calcium food items that have been tested for bioavailability.

If you can get your calcium from items on this list and you won't have to worry about supplement timing.

Food Serving Size Calcium absorbed per serving

Collard greens 1 cup cooked 173mg

Canned salmon (6 oz with bones) 1 6-ounce serving 114mg

Turnip greens 1 cup cooked 102mg

Milk, Lactaid, yogurt 1 cup 96mg

Cheese (hard such as cheddar) 1 ½ oz 97mg

Sardines (with bones) 1 can (3.75oz) 95mg

Bok choi 1 cup cooked 69mg

Broccoli 1 cup cooked 57mg

Kale 1 cup cooked 46mg

Mineral water 20oz bottle 41mg

Mustard greens 1 cup cooked 42mg

Chinese spinach ½ cup 29mg

Almonds 1/4 cup 22mg

Beans (white) 4 oz 25mg

Beans (pinto) 4 oz 15mg

Beans (red) 4 oz 10mg

Whole wheat bread 1 slice 17mg

The following is an example of an easy to follow regimen which provides 1000% of the daily bioavailable calcium requirement from natural foods.

1 cup of milk or yogurt, (either regular or lactose free) 96mg

2 ounces of low fat hard cheese 129mg

1 can of sardines, 1 serving salmon, or a third portion of dairy 95mg

400mg of calcium citrate (21% elemental calcium) 84mg

Total 404 mg

PMRpro profile image
PMRproAmbassador in reply to Admiral06

You are talking about NORMAL HEALTHY people's RDA. The idea of the supplemental calcium alongside corticosteroid therapy is to protect against bone density loss without having to resort to bisphosphonates in the first instance. I can't find the reference - but a study has shown that having extra calcium in the form of supplements does do that with no risk of side effects.

There is also a trap in your list of foods: it is only appropriate in the USA. Few foods in Europe are fortified with calcium and vit D. I won't get into a discussion as to whether that is a good or bad thing - but it is so.

HeronNS profile image
HeronNS in reply to PMRpro

Surely only bread and dairy would be affected by fortification - not vegetables or tinned salmon?

PMRpro profile image
PMRproAmbassador in reply to HeronNS

True - mea culpa. However, overall they are probably significant.

Interestingly, until quite recently I was not allowed to eat most of those green veg - they are a no-no if you are on warfarin-type anticoagulants.

With tinned salmon and sardines you are supposed to eat the bones,.. Tinned salmon is bad enough - the bones too would be the end!

HeronNS profile image
HeronNS in reply to PMRpro

I haven't had either tinned salmon or sardines for years. But as a child I particularly liked the bones!

PMRpro profile image
PMRproAmbassador in reply to HeronNS

I thought you were strange... ;-)

HeronNS profile image
HeronNS in reply to PMRpro

😜

Rugger profile image
Rugger in reply to PMRpro

You'll think me strange too, but I always eat (and like!) the bones in tinned fish and the little roes in pilchards are scrummy!

I take a huge amount of dietary calcium - keep meaning to calculate exactly how much. If you do find that reference that might free me / us from the bisphosphonate, please do share it with us.

PMRpro profile image
PMRproAmbassador in reply to Rugger

Rugger - Having a dexascan is the best way to approach that. If your bone density is high enough you shouldn't be on AA.

Rugger profile image
Rugger in reply to PMRpro

Sadly, a DEXAscan in January showed I do have osteoporosis, having been on pred for 9 months, but I'll never know what my bone density was like before diagnosis. I misunderstood your reply and thought that I might get away without the Risedronate and just manage with my dietary and supplemental calcium. I know that HeronNS might say give it a try, with increased walking etc. I am trying to up my activity - walked along the Prom at Scarborough yesterday!

PMRpro profile image
PMRproAmbassador in reply to Rugger

It depends on the readings - Heron was wrongly told she had osteoporosis when in fact it was just osteopenia, albeit fairly advanced at -2.1. She got the same reading to -1.6 in a year with a dietary and exercise approach.

By - bet that was fun - didn't you get blown away? My daughter is a paramedic in Whitby...

Rugger profile image
Rugger in reply to PMRpro

Yes, my readings are -2.6, -2.8 and -3.1.

I suppose I was thinking if I could improve my readings by 0.5 by natural means like Heron, that would be a better way than with bisphosphonates, in view of recent news.

We were lucky with the weather - a still day, with sunshine and clouds, but not a drop of rain until the journey home to West Yorkshire. We like Whitby, but were visiting friends who have moved to Hackness, so Scarborough was nearer to their home.

PMRpro profile image
PMRproAmbassador in reply to Rugger

But you can do both - and be able to stop the bisphosphonate once your scan readings are better.

Rugger profile image
Rugger in reply to PMRpro

Yep - that's my hope / intention!

HeronNS profile image
HeronNS in reply to Rugger

I don't think your scan results are particularly dire. A couple of them are barely over the fairly randomly selected osteoporosis line. If you follow the natural route, plus make sure you learn techniques to protect your spine if your doctor considers you may be vulnerable to compression fractures, you should be able to improve your bone density as quickly with nutrition and exercise as you can with the drugs - and no side effects except generally better health!

Research has been done showing that micronutrients can improve bone density. You don't have to measure everything out as they did in the experiment, but here's an article to get you started:

hindawi.com/journals/jeph/2...

Rugger profile image
Rugger in reply to HeronNS

Thanks Heron - food for thought!

altywhite profile image
altywhite in reply to PMRpro

I agree....sorry...don't do fish bones of any kind!!

HeronNS profile image
HeronNS in reply to altywhite

Well, altywhite, you do know we are only referring to the little gently crunchy bones in tinned fish which can't possibly do you damage when you swallow them?! Liking or disliking is probably a texture thing. I remember the horror of having to eat tripe when I was a youngster. I used to swallow the pieces whole, unable to bring myself to chew them. 🤢

altywhite profile image
altywhite in reply to HeronNS

Oh crikey Heron....the dreaded tripe!! My mum used to serve it cold with pepper and vinegar!! She swore blind in later years that she never used to make me eat it!!! But she did!! Haha. And yes....the bone thing is definitely texture!! 😀

HeronNS profile image
HeronNS in reply to altywhite

OMG, hot was bad enough!

Ronnie101 profile image
Ronnie101 in reply to PMRpro

I'm on rivaroxaban, and I can't find any reference to avoiding greens with this anticoagulant. Should I raise it with my consultant do you think?

PMRpro profile image
PMRproAmbassador in reply to Ronnie101

No - it is one of the new generation anticoagulants which work in a totally different way . It is warfarin and its relatives that are a problem, they work by an effect on the vit K pathway in the clotting cascade. Dark green veg are high in vit K1 - kale and spinach are particularly high. The better things of the new generation ones are not having to worry about what you eat - and no blood tests! Not that the cranberry thing was ever real - the patient in whom they found the massive INR was a cranberry farmer - and literally drank gallons of cranberry juice!

Admiral06 profile image
Admiral06 in reply to PMRpro

None of the items on the list I provided are fortified with calcium, and 350 - 400 mg of bioavailable calcium from foods is the equivalent of taking 1200 mg of supplemental calcium. The reason being that only 13-40 % of supplements can be assimilated by the digestive system and incorporated into the bone. .

It has also been shown that a calcium rich diet is protective of the heart while calcium supplementation may damage the heart. Additionally, hypercalcemia, (a shift in the body's acid/base balance towards alkaline), calcinosis and nephrocalcinosis, (calcium deposits in the tissues and kidneys), kidney stones, plaque in the arteries, and an increased risk of heart attack, stroke, and kidney disease has been linked to taking milk with calcium supplements in the wrong ratio.

Furthermore, although taking calcium with vitamin D may offset metabolic problems caused by steroids, no amount of supplementation will prevent fractures. The latest studies also show bisphosphonates are problematic and their value in preventing fractures is in question.

The following link is just one of many that demonstrated the advantages of a calcium rich diet over supplementation: hopkinsmedicine.org/news/me...

altywhite profile image
altywhite in reply to Admiral06

Hi admiral, thanks for the info. I consider myself to have a pretty good balanced diet and luckily like most of the foods rich in calcium....except fish bones! I will continue with my D3/calcium though as I have been on quite high doses of pred for the last 2years (not so much now...down to 12mg) and I can't/don't want to take bisphosphonates. Maybe I'll get my levels checked at my next blood test.

hiandri profile image
hiandri

Hi altywhite,

It is definitely a mission remembering to take all your meds. I have done a table landscape for the month, stuck inside the cupboard door and using a highlighter just cross off each box during the day as I take them so i know I have taken it - it works quite well for me.Regards John

Zebedee44 profile image
Zebedee44

I didn't know anything about not taking them at the same time, can anyone tell me what the reason for that is please? I write everything down, including pain symptoms, and find it very useful if a little hyperchondriacal!!! Is that a real word?

HeronNS profile image
HeronNS in reply to Zebedee44

Prednisone interferes with the absorption of calcium. Prednisone does more, changing the formation of certain bone building cells, but at least by taking calcium at a different time we can maximize calcium intake.

ncbi.nlm.nih.gov/pubmed/758...

Jo1947 profile image
Jo1947

You’ve read my mind Altywhite! Just yesterday I had decided to ask for help on the forum re timing of meds. I also take levothyroxine and have very confused about when to slot it in. I have been taking it at night but have forgotten it a few times. I am on a slow reduction to 6mg prep and am feeling so so fatigued, I have never felt anything like this, even with the underactive thyroid I could manage the tiredness. I will follow your plan I think and see how it goes, thanks

PMRpro profile image
PMRproAmbassador in reply to Jo1947

Dosette box and alarms on your phone!!!

Jo1947 profile image
Jo1947

Yes need a new dose box, other one fell apart and I have been winging it, over last few weeks an d I know I have missed a few doses as I can’t remember if I’ve taken tabs or not! Havnt used phone reminder yet but will start using it it, thanks for suggestions. Only just realised this post was from 2 years ago, dah knew I was confused 🤷‍♂️

PMRpro profile image
PMRproAmbassador in reply to Jo1947

It's happened a lot recently - don't worry about it!

altywhite profile image
altywhite in reply to Jo1947

Hi there, don’t worry, I’m always finding myself looking at old posts!! I have 3 dosing boxes 😀 One is by my bed so as soon as I wake I now take my levothyroxine, then downstairs and pred after breakfast with my B vitamins and vit k2. I’m down to 6 mg now....I’m a slow reducer out of necessity. It’s Adcal after lunch and dinner then at night magnesium and aspirin!! 😀😀 So you see not much changes, it’s still a minefield!! Good luck.

Jo1947 profile image
Jo1947

Hi Altywhite, thanks for your reply. What B vits do you take? I have to have B12 as an injection every 3 months for life so wonder what others to take. Has your doctor prescribed the aspirin? I am going to follow your regime so will get some more boxes for different times of the day, am also now steadying at 6mg of pred, don’t know how long to leave it before starting reduction to 5mg

altywhite profile image
altywhite

Hi Jo,

I just take a Vit B Complex, I get it from Healthspan. I just thought I should boost my intake, my grandmother had pernicious anaemia so I'm just trying to cover my options. :-)

And yes, my GP prescribed the aspirin. One of the other partners tried to get me to stop it last year but I don't have any problems with it and a strong family history of strokes so I was told to continue with it.

I've been hovering around 6mg for a couple of months now. Had a little blip around Christmas so upped it slightly for a few days but then went back down.

Since I got below 10mg I've had to reduce very slowly, 0.5mg at a time. It's amazing what that half a mg can do!!! So I reduced using my own version of the DSNS plan and once down to the next dose I've tended to stay there for about a month before starting again.

Everyone is different though...my plan wouldn't work for some, it might not be quick enough but it's what I've learnt to do. I'll start down to 5.5mg at the end of January, all being well.

As for the fatigue....if you search for it on the site...and brick wall!!! :-) you will find lots of others in the same boat. Good luck. Am always here to help if I can.

Linda x

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