LFT - ALP is up total bilirubin is down

[danaLL]

In my recent blood test, my ALP tripled but my total bilirubin went from 1.0 to .9. I also recently did an MRI where the doctor said there was no further progression of the disease in the last three years. Has anybody experience this or does anybody know what this means? I see my doctor in a week to go over the test results.

[danaLL]

Actually, my ALP doubled

[gwillistexas]

danaLL...I can’t answer that. I’m sure someone here has better insight on it. Do you take Urso? I had my hepatic lab this afternoon. Always nerve racking waiting for results. We never know which way enzymes will go. Maybe your dr will have a good answer for you. Take care🌺

[danaLL in reply to gwillistexas]

Thank you gwillistexas. I am on urso, have been on it for almost 9 years since I was first diagnosed. I am guessing that ALP can fluctuate a lot and that total Billy ribbon is a better measure of the progression of the disease. I am not too stressed but I do hate waiting for test results.

[gwillistexas in reply to danaLL]

You’re welcome. I remember my dr saying ALP & bilirubin are the two he watches mostly, for now. I’m sure if my AST & ALT were elevated he’d watch those also. He did say bilirubin may fluctuate. So many variances with this mess. Pls let us know what your dr says about ALP.

[Pamela4475 in reply to danaLL]

Dana my doc told me liver health is reflected in tests..... pt, ptt , bili, albumin, and lastly all phos..... I also had a lab error once so go by the other labs and how you feel..... I find myself worrying too

[danaLL in reply to Pamela4475]

OK, thank you so much Pamela. The rest of the levels were normal range. The AST and AL T were slightly elevated. I’m hoping it’s just some food or activity or something that caused a temporary spike. I will post again when I see my doctor

[Pamela4475 in reply to danaLL]

Mine too and he said “watch your carbs”

[danaLL in reply to danaLL]

Also I’m assuming PT is protein I’m not sure what PPT is

[Mirimaur in reply to gwillistexas]

Hope you get good results Gwillis , thinking of you . It is so nerve racking

Miriam xx

[gwillistexas in reply to Mirimaur]

Mirimaur...thank you. 🦋

[ninjagirlwebb]

Alk Phos are not specific to the liver. Levels of alkaline phosphatase -- an enzyme in the blood -- can be elevated by liver disease, or less serious conditions including pregnancy and over-the-counter drug use. Best to have your doctor answer that question.

Per PBC treatment guidelines for doctors: Evaluate all patients for their stage of disease using a combination of non-invasive tests (bilirubin, alkaline phosphatase, aspartate aminotransferase, albumin, platelet count, and elastography) at baseline, and during follow-up.

Elevated serum bilirubin and ALP can be used as surrogate markers of outcome for patients with PBC, and routine biochemistry and hematology indices should underpin the clinical approaches to stratify individual risk of disease progression.

[liver-bird]

Hi

I hav been on urso for 4 years and now my ALP has risen ( don't know by now much). My GI has ordered an MRI of my liver to see if the cause is there. Waiting for the MRI appointment. Apprehensive as this is first time any results have risen. Good luck, let us know how you get on. Diane

[gwillistexas in reply to liver-bird]

good wishes for you. Hope all will be okay.

[danaLL in reply to liver-bird]

Good luck with your test. I’m sure everything will be fine. After almost 9 years of having this, my levels have risen but according to my doctor I’m still very healthy my disease is progressing very slowly. Try not to stress is that is worse than any bad food, drink or anything else you can do your body !

[Dodo8 in reply to liver-bird]

I have had PBC for 26 years. My tests go up and down and never know why. I'm on Ursofalk and Imuran. I still work and can manage my life. Try not to worry too much, do not stress, rest when you feel you need it. Be aware of what you eat and drink and you'll live a long life. I'm 59.

Gold luck, lot of energy and happy days to you!

[gwillistexas in reply to Dodo8]

Dodo8...thank you for that encouragement. Seems you have managed very well🦋

[liver-bird]

Yes thanks dodo for your kind words 😃