Does anyone who is in early stages of PBC feel tired all the time? I have to take a nap every day and go to bed early. I was diagnosed early this year and starting last fall (a year ago) I have required lots of sleep. I take Ursodiol and it lowered my liver enzymes so it seems to be working. My biopsy showed only inflammation and that was before starting urso. No fibrosis.. my doctor thought I should be feeling better now that my enzymes are in normal range. I don't think he really understands PBC even though he is a hepatologist.