I was diagnosed with PBC back in 2002 at the age of 21. I have been taking close to 1000 mg of urso everyday since then. Maybe 6 years into it my puritus would kick in the week before I began menstruating. Then once my menstruation began it would go away. Over the past three months the puritus has been horrendous. Just has not really subsided. After my most recent check up with my specialist she felt that the urso is no longer working. She told me about a new medication called Ocaliva. I was wondering if anyone is taking this with some details. They say this could stop my itching and lower my numbers. Has anyone had any luck with this new medication? All help is appreciated. Feel free to ask any of your own questions I will help in anyway I can.