pbc

[hay65]

just wondering how many people have rhs neg blood who have pbc?

[Hidden]

Hello hay65.

Interesting as blood isn't something I've actually thought about with having PBC, well as in blood groups that is!

Well I have to say that I am O positive which is pretty much the most commonest apparently. I was looking on the National Blood Transfusion website short time ago and found this to be an interesting piece. Now you have got me wondering if there is anything in it all...??

"Antigens and antibodies

Your blood group is identified by antigens and antibodies in the blood. Antibodies are part of your body's natural defences against invading substances such as germs.

Antigens are protein molecules found on the surface of red blood cells. Antibodies are proteins found in plasma. Antibodies recognise anything foreign in your body and alert your immune system to destroy it.

The ABO system

There are four main blood groups defined by the ABO system:

- blood group A has A antigens on the red blood cells with anti-B antibodies in the

plasma

- blood group B has B antigens with anti-A antibodies in the plasma

- blood group O has no antigens, but both anti-A and anti-B antibodies in the plasma

- blood group AB has both A and B antigens, but no antibodies

Almost half (48%) of the UK population has blood group O, making this the most common blood group.

Receiving blood from the wrong ABO group can be life threatening. For example, donated group B blood contains anti-A antibodies, which will attack group A cells if given to a person with group A blood.

As group O red blood cells don't have any A or B antigens, it can safely be given to any other group."

I would now be interested in finding out more as could there be some connection as to how we develop PBC? Might not be correct as I'm no scientist but could it be possible that the ones who do develop PBC in this case as that is what we have, all have a blood group that consists of certain antibodies as I have not failed to notice that the blood groupings, AB doesn't contain any.

How we are said to be 'positive' or 'negative' follows on the same site by this explanation:-

"The Rh system

Red blood cells sometimes have another antigen, a protein known as the RhD antigen. If this is present, your blood group is RhD positive. If it's absent, your blood group is RhD negative. This means you can be one of eight blood groups:

A RhD positive (A+)

A RhD negative (A-)

B RhD positive (B+)

B RhD negative (B-)

O RhD positive (O+)

O RhD negative (O-)

AB RhD positive (AB+)

AB RhD negative (AB-)

About 85% of the UK population is RhD positive (36% of the population has O+, the most common type).

In most cases, O RhD negative blood (O-) can safely be given to anyone. It's often used in medical emergencies when the blood type isn't immediately known. It's safe for most users because it doesn't have any A, B or RhD antigens on the surface of the cells, and is compatible with every other ABO and RhD blood group. "

[hay65 in reply to Hidden]

yes this does interest me also,i im rhs neg A

[Yvonne22]

I'm A rhs neg.

[Hidden]

My mum was rhesus negative but i have positive A , I have pbc.

[Rosie2410]

I have Pbc and I'm blood group b positive

[kimphoebe]

Hi yes I have r h neg blood group and have stage 3 pbc

[doublewhammy]

O rh negative pbs/aih overlap

[Steelie]

Yes I'm reshus negative

[liver-bird]

I'm O positive and have pbc

[Hidden]

I'm A+ and have PBC Stage 4.

[CheryllandDene]

I am O negative

[Francescadavenport]

Hm, I'm AB neg. and have wondered if there was any link to PBC.

[Jo53]

I'm A+

[GillianB]

I'm A B postitive

[donna01]

I'm A+

[Hidden]

I am certain that I am O positive and wanted to verify at my GP surgery. Emailed the surgery and the first response I was asked for more information on myself and then the final reply is that it cannot be found in my records! (This is the paper ones too.)

I recall being informed of my blood group when I was pregnant many years ago and 'past problems' (I find this an odd statement on my partial medical records online) it stated when I had my children (with unproblematic births!) and it was also noted when I once to give blood in town.

I shall have to see if I can verify this with my GP when I go and see her in the future. I shall see if the nurse has any idea when I go for the repeat bloods early 2016.

I know it's not anything critical but I personally think it is something fairly simple and straight-forward a question to ask and moreso I have been in hospital in the past for what is now considered minor surgery and know my blood group was taken then as it usually is if anyone is having an operation.

[Kimmy1972]

Hi I have rhs negative blood group I was diagnosed only weeks ago

[2014-maydayyeah]

I am A rh positive and just had a liver transplant at end of June and delighted to say am doing great so far. x

[Hidden in reply to 2014-maydayyeah]

Where did you have the transplant? Best wishes for a good recovery

[2014-maydayyeah]

Hi I had my transplant in Kings College Hospital London. How are you keeping?

[sophie666]

Im rhesus a negative i have stage 4 pbc and overlap syndrome x

[Nitawese]

My sister who was A negative with a D antigen passed away last May from PBC. I have wondered if the A negative blood type could have been a factor. My brother and I are both O positive, and have no indications of liver disease. My maternal grandfather, who was A negative, died from liver cancer back in the early 70's. Just wondering about the propensity of blood type related to pbc since it is regarded as an autoimmune disease.

[Hidden in reply to Nitawese]

Hello Nitawese.

I am O positive I have found as I wasn't sure earlier on this site.

It's said that others in a family can acquire the same auto-immune condition but it doesn't seem the case with a lot.

I do think anyone can succumb to cancers and it is more than likely that your grandfather's was unrelated to your sister who had PBC.

It is apparently said that anyone with PBC is more than likely to die having it as opposed to it being the cause that was something else.

I think until it is known how we acquire PBC (I was diagnosed Dec 2010) then there is very little we can do to actually take steps to avoid getting it. I'd never even heard of it until 6 months before I was diagnosed and then I never even mentioned to the GP as I stumbled across it in a library ref book first. I'd never been a smoker nor drank much in the way of alcohol (though this is a misperception as it doesn't cause PBC but it can of course cause liver damage) and thought I did take good care of myself and hadn't seen a doctor in some years (I was 45 when I started itching) but then I was told I had PBC.