Megadose of hydroxocobalamin - Pernicious Anaemi...

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Megadose of hydroxocobalamin

topher2018 profile image
11 Replies

After researching the different types of b12 shots I decided to forego ny regular 1000 mcg shot of cyano and try a shot of hydroxo from a private provider. After the shot the provider told me it was a 7 mg shot. This week - a couple days after the shot - I have been quite dizzy and off balance. Any possible connection? This shot was my third weekly loading dose after 5 daily loading doses. So all total I had 5x1000 mcg cyano over the course of about 7 days and then 2 x1000 mcg cyano weekly for two weeks. I also had one shot of 2000 mcg methyl prior to the megadose shot.

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topher2018
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clivealive profile image
clivealiveForum Support

Hi topher2018 if you are in the U.K. may I ask where on earth you are getting your cyanocobamalin 1mg injections from?

You are probably urinating most of your megadose shot. I think I had something similar back in 1968 and 1972 when I had two Schilling tests at which time I had a massive B12 injection also had to drink a glass of radioactive B12 and my urine was measured over the next 24 hours or so. Can't remember now whether I felt dizzy but I wouldn't be surprised.

topher2018 profile image
topher2018 in reply to clivealive

USA. Standard over here. Do you prefer cyano to hydroxo?

clivealive profile image
clivealiveForum Support in reply to topher2018

I've been on cyano for 46 years and didn't get on with hydroxo. Sadly there is a Europe wide shortage of cyano at the moment.

Gambit62 profile image
Gambit62Administrator in reply to clivealive

hi clivealive - surprised to hear about europe wide shortage of cyano - looking at the site I normally use to source my injectable B12 all the cyano seems to be on special offer at the moment so doesn't appear to be any sort of shortage in germany.

clivealive profile image
clivealiveForum Support in reply to Gambit62

My Pharmacist cannot get any, N.I.C.E/NHS have "discontinued" it and the German site recommended to me was still sold out (again) yesterday when I looked.

I have enough till the end of September so hopefully it will became available again before then.

Thanks Gambit62

topher2018 profile image
topher2018

The other odd thing is that the dizziness seems to get a bit better (but still there) after I have a sublingual methylcobalamin tablet (1000 mcg). Could a megadose cause my body to purge too much or develop a resistance to b12?

clivealive profile image
clivealiveForum Support in reply to topher2018

I don't know the answer to that - sorry.

It's my bedtime now so I'll bid you goodnight.

topher2018 profile image
topher2018 in reply to clivealive

Good night. Thanks Clive.

fbirder profile image
fbirder

So you’ve had about 16 mg over a few weeks.

If they were treating you for cyanide poisoning they would give you 10,000 mg in a single day. Now that is a megadose.

stichtingb12tekort.nl/weten...

NorthallertonBob profile image
NorthallertonBob

Ordinary common sense would suggest that if everything was fine and then you started to accept an out of the ordinary procedure and then developed odd symptoms then I would suspect that the new procedure would be the cause of the unwanted side effects.

Try stopping the 'new' treatment' and see what happens.

A bit like saying: I usually drink one bottle of wine in the evening .... but if I have two and a half bottles of wine I feel dizzy. What should I do?

Answer: Go back to one bottle of wine per evening and see if the dizziness goes away.

Ryaan profile image
Ryaan

Agree with Northallerton.

Also the excess, your body will get rid of through urine.

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