I've been taking 10,000-15,000 mcg oral methylB12 and 400 mcg methylfolate. I just received my Oxford BioSciences methylB12 injectable. My doctor said that even though my transcobablamin B12 binding capacity is deficient, that the protein needed to carry it into cells isn't being executed properly, this is ok because I am supplementing B12. I forgot to tell her that I'm taking daily 10,000-15,000 mcg methylB12, a hefty amount. I am hoping that switching to injectable B12 will help my symptoms. My B12 related bloods:
Transcobalamin B12 binding capacity = 780 (825 = (or was it 800)-2000) - Dec 2017
Serum B12 = >1500 = (180-914) - Dec 2017.
Previous Serum B12 was 637, July 2014, after 5 months 10,000 mcg.
MMA = <0.10 = (0.00 - 0.40) - Oct 2016
Folate = >22.3 = (>5.9) - Oct 2016
I gave myself a test dose of methylB12 injectable, 3000 mcg in the reconstitute (Oxford only sells dry methylB12 and as per instructions, I reconstituted it with sterile saline). I noticed that my nausea, dizziness and weakness subsided for awhile, which was very nice. Given my above numbers, what should my dosage and frequency be?
I do have one autoimmune disease. I don't have intestinal bacteria overgrowth (tested). I did have cryposporidium treated two weeks ago (tested). I have an ulcer from NSAIDS (biopsy). I have some sort of iron absorption problem. Ferritin is now increased to 54, but other iron values now indicate iron toxicity.