2ml or 1 ml solution?

[wedgewood]

I'm just wondering why some B12 ampoules of 1 mg are offered in different amounts of solution . Is there a particular advantage or disadvantage with either?

[scorpiojo]

I sort of asked that below and was told some are a mix of solution and water or saline... Hope you get an answer 😊

[engels in reply to scorpiojo]

Not quite right. B12 is manufactured as a crystalline powder which is dissolved in water so it can be injected and different manufacturers, for whatever reason, dissolve it in different amounts of water. Various concentrations are available e.g. 1mg/1ml, 1mg/2ml, 1.5mg/1ml, 5mg/1ml etc.

I've never come across any research into the various concentrations. I use hydroxo, mainly in 1mg/2ml concentration which I find slightly more comfortable for intramuscular injection than 1mg/1ml.

[wedgewood in reply to engels]

Thanks for that engels .

[scorpiojo in reply to engels]

Glad you clarified thanks 😊

[deniseinmilden in reply to engels]

Fascinating Engels - I thought the lower the volume the better - I hadn't thought about the consequences of concentration! Saying that, I use 1.5 mg in 1 ml and never find any problem with the solution but I guess I'm lucky.

Thank you!

[fbirder in reply to scorpiojo]

I'd be surprised if any of them were in plain water. Saline is much kinder to the body.

[scorpiojo in reply to fbirder]

Great you answered... I knew it was something like that I just couldn't recall accurately...😊

[engels in reply to fbirder]

You're quite correct of course. The good old salt and vinegar are added as well as the water.

[humanbean in reply to engels]

Vinegar? Owwwwww!

[nomizo]

Hydroxocobalamin comes as hydroxocobalamin acetate. It is dissolved in water along with sodium chloride, acetic acid and/or sodium hydroxide. Here, UK, it is typically 1mg in 1 ml. In parts of Europe it is typically 1 ml in 2 ml.

In other words (I joke a tiny bit), it is dissolved in a solution of salt and vinegar and/or violent cleaning stuff. Very good for your fish and chips and/or cleaning the sink. Trouble is that the 1 mg in 2 ml contains so much more salt and vinegar that it stings like hell, so I am grateful that I get the 1 mg in 1 ml and I am astonished that Engels prefers 1 mg in 2 ml. But some people like sugar in their tea, others do not. Each to their own. But I speak after 28 years of fortnightly injections, so I am an "expert" - or just old, as the case may be.

So, seriously, the only advantage to me, and others might differ, is that the less the quantity for the same dose, the easier it is to inject and the less the discomfort. Part of the discomfort comes from the fact that it is an intramuscular injection. The injected fluid has to squeeze in between muscle fibres and splits them apart. The less one does that, one would suppose, the better. The main reason for 1 mg in larger than 1 ml amounts of solution is, I believe, the ease of manufacture.

[wedgewood]

I thought that I had sent you some Hydroxocobalamin I week ago with all the necessary . what happened. ?