MTRR A66g and MTRR 11 double snips and B12

[davidpa]

I have double snips in the above genes and so I think re-cyling B12 is compromised. Gambit, Clare and May may find this interesting. Wikipedia article on Allergic rhinitis and scroll down to management using B12.

[fbirder]

Hmmm. I've just checked and I have two mutations on that gene - rs2287780(C;T) and rs3776463(C;T) - both of which are only present in 5% of the population. So the combination should only be in 25 per 10,000 people.

Here's a description of this gene -

"Yasko Methylation Methionine synthase, coded by the MTR gene, has a B12 attached to it. The Methionine synthase takes a methyl group from methyl folate and attaches it to its B12, then it attaches it to a molecule of homocysteine, turning it into methionine, which in turn becomes SAMe. After 1000-2000 times doing this, the B12 gets turned into a useless form, and MTRR turns the B12 back into the useful form so that the molecule of MTR can keep working. The MTRR mutations make this enzyme less active, suggesting a need for more B12."

[Serendipity16 in reply to fbirder]

Hi

I wondered where you got the genetic info from? Thanks

[fbirder in reply to Serendipity16]

Hi,

A few years ago I had my autosomal DNA tested at FTDNA. This was done purely for genealogical purposes. I was investigating my family tree and wanted to see if any relatives had also been tested (the answer was 'no').

Some time later I discovered a website - Promethease - that, for a very small fee, would check your data for known medical mutations (Single Nucleotide Polymorphisms - SNPs or snips).

On FTDNA - familytreedna.com - the test is called 'Family Finder' and costs $99 (a lot cheaper than when I had it done).