I have been on Mucuna pruriens for 4 weeks. I had decided to go off most of my Parkinson's meds or at least decrease the doses because of the headaches I was getting from gritting my teeth. The same thing happened to me when I took Paxil and stopped when I went off it. I titrated off azilect and 1 1/2 g requip substituting 3/8 tsp. MP. I continued taking sinemet 100/25 3x daily plus the MP 3x. I could not increase the MP dose to eliminate or decrease my sinemet without feeling agitated. My restless leg has gotten so bad to be unbearable. Last night my big toe was on fire....beginnings of gout? I read levadopa and diuretics can be a risk factor. So after weighing my options I am going to go back on my requip and maybe azilect at a reduced dose.....and stop taking the MP. I wish I could have stopped all my Parkinson's meds and substituted MP......but it hasn't worked out for me. I can't help think the MP has resulted in the problems I am having now. I had such high hopes.