Does anyone wake in the night unable to move?

[batwing7]

I have been taking about 1000mg of Sinemet for most of the past 5 years.

More recently I have had to come off Amantadine due to difficult s/e.

Now I find with Sinemet acting as a mono therapy I am feeling much more disabled.

Any thoughts out there?

[billw91]

I also get very weak during the night at times. I tried taking a controlled release Sinemet when I went to bed, but it did not help. Sometimes it takes every bit of energy just to turn over, although once I get out of bed (to go to the bathroom) I can walk as well as I can during the day.

It's a shame you can't take the amantadine. I took two per day (100mg) for years and my neuro recently increased it to three and I am doing much better.

[batwing7]

Yes Bill. I have developed a condition called livedo reticular is from taking Amantadine. I was wondering what else there is to do or take. The feeling of being a 'dead weight' must be quite a widespread problem for pwp especially in the night.

[Hidden]

Before I got the diagnosis, I always woke up in a state unable to move during the night even though I was aware of everything around me I could not move.

Now it only happens occasionally.

[hanuman]

Yes my arms in particular can feel so heavy and difficult to move. It's awful and I hate it.

[Helenxxx]

No "answer" but any tips very gratefully received!!! My husband has great difficulty getting out of bed at night and needs my help. Night and day, legs are weak AND painful. Slow release tramadol not helping. Tips on meds or "how" to get out of bed gratefully received!!! He has a bed stick and a monkey pole!!! Thanks

[froggatt55]

Sorry you have had to give up Amantadine. Have you tried Azilect?

[Hikoi]

Or entacapone?

[Hikoi]

Batwing concerning the side effect are you referring to the common side effect of discolouration of your lower legs? If so its interesting that you then had to stop amantadine unless you had other complications. If it was simple discoloration I dont think everyone stops because of this and it may be worth checking out with others.

[aspergerian]

The first several posts in this thread illustrate a problem: the continuing of the pretense, the overemphasis that dopamine is the only neurotransmitter of concern in PD .