23AND ME REPORT

Just received my 23andme results. It states that I have less than average risk for PD. I perceive this as indicating a probable environmental factor. I grew up in rural Illinois in the 50's. I suspect the use of herbicides was high, but there must also be a different genetic factor that is triggered otherwise all of the other residents should be inflicted too.

My greatest risk... Alzheimer s. My wife has known this since we met.

17 Replies

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  • Good luck with your 23 and Me results. I am still ploughing my way through them after about 12 months. I also am a very low risk of getting Parkinsons - I don't really understand this result but asssume it is because I don't meet the criteria which could cause it. I also don't have the gene which means I could pass it on to my family which is very good news. I always complete the surveys and for the most part am glad I took the initial test. I have not found any close relatives so far.

  • I also was low risk and no gene. I thought was funny not really because i have pd. No one in my family does but me. I found the info interesting. Also worked around pesticides i don't know i really just want something to blame it on

  • Me, too

  • We just got my husbands 23andme results yesterday. Trying to read and figure them out. It looks as if he has typical risk for Parkinson's and does not carry the Gene. Strange thing about that is, His father had young onset Parkinsons (like my husband) and was involved in many trial studies. Medicines my husband is taking now. Thank you Dad. He was found to carry the gene along with several other members of his family that have not developed the disease. One uncle and 3 great aunts on his Dads side did get it. Now my husbands mother was diagnosed 2 years ago at age of 75 not long after my husbands diagnosis. How can he not be carrying the gene? Are we reading it wrong? They were farmers of lots of land until my husband was 16 and did use paraquat and other pesticides.

  • I have the same results. Low risk. I know what caused my PD. Lead poisoning. I used to pump leaded gasoline. Remember when we had full service stations, nobody turned their car off and the gas tank was behind license plate. I breathed a lot of gas fumes starting at age 13 until I was 21. I enjoyed the scent back then. If I only knew.

  • We have been doing research about pesticides and PD. The Jan/Feb 2012 Sierra Club magazine has an in depth study in Central California about PD and pesticides. The circumstances around my birth in Southwest Ohio in the summer 1952 when my Mom was pregnant with me is strikingly similar! My parents lived in a rural area, high amounts of pesticides (DDT, paraquat), and well water. Well water likely contaminated and affected gene when I was born in 1953. This is not gospel but highly likely. I'm still reviewing 23andme results.

  • I also had no trace of the gene but spent summers on the farm in Minnesota. So far I'm only family member to get PD that I know of. A few relatives developed dementia as they got up there in age. Anything I can do to find the cure or, better yet, prevention, I will!

  • My understanding is that there is limited information on genes and PD and 23andme are only looking at a few specifically known. So, the majority of us will fall into the typical, lower than average risk category. In fact, I haven't talked to anyone yet that falls into the higher risk category though we have PD. For example the LRRK2 gene is present in less than 10% PD patients BUT if one does have they have a >~ 75% chance of developing symptoms.

  • LAst year I took advantage of 23andMe's offer of a free test for people already diagnosed with PD. It turns out I have two rare mutated genes (LRRK2 [The variant reported by 23andMe, rs34637584, also known as the G2019S mutation, is the best-studied LRRK2 SNP related to Parkinson's in individuals with European ancestry) and GBA (The GBA variant that 23andMe reports corresponds to the N370S mutation, not that I know what that even means). A double-header! They listed my risk for PD as 86.7%. This information had two good effects on me. It didn’t allow me to entertain any denial fantasies, and it took away any feeling that getting PD was my fault or anybody’s fault. It just is. (I had an urban upbringing and my parents were meticulous about washing all fruits and vegetables.) When I told my older daughter that I had two rare mutations she looked me square in the eye and replied, dead-pan, “That explains a lot.”

    The 23andMe report also showed me at a nearly 50% risk for macular degeneration. I immediately scheduled an appt. with my eye doctor, just for nice. I'll see her again tomorrow.

    The Parkinson's Institute recruited me for a study and between them and 23andMe they arranged for genetic testing for my parents (dad has PD,) my sister, and my daughters (aged 20 and 23). They all considered the possible outcomes and elected to take the tests.

    When I allow myself to worry about it I shudder at the thought that through no fault of my own I have passed this ridiculous condition to my dear children. And if so they will KNOW. Are they better off knowing ahead of time? I dunno.

    I do suggest that all PDs (PiDdlers?) get tested. It's quick, easy, painless, free, and helps the research.

  • Thanks for the information,but what is it and where do you get it done?

  • private company that does genetic testing in USA

    23andme.com/?gclid=CIqczY-k...

    they mail you a kit, you spit in a tube, and send it back

  • I too recieved my results from 23 and results, I do have the LRRK2 gene with a G2019 S mutation. My risk of PD was typical, I do have PD, with no visible tremor. My maternal grandfather had PD, maybe there is an inherited aspect. My paternal gm had alzhiemers, I also have.the gene for that, with a higher than typical risk, and genetic indications for a longer life. Go figure, hoping it works out to only one of the first two work. Especially if number three works.....8)

  • Same results here, low prob.of PD but diagnosed at age 50, One interesting phemnom-no known history of either side of the family going back multiple generations.Am third of eight kids and no one else has diag. My mother thinks it's becausec I had mumps menignitis--I think it was related to car crash with mild traumatic head injury six months before diagnosis. Any comments ?

    D yet

  • Thanks to all. Although my career of 30+ years was Physical Therapy, I was an orthopedic manual therapist; I did not see many neuro patients for the last 15 years.

    The main reason I chose an ortho approach was twofold. The first was that ortho patients were likely to experience fast recoveries with excellent potentials... happy quickly. The other reason was that the neuro sciences were in their infancy relative to other aspects of medical science. They still are.

    Despite the advances in the study of the human genome plus the epigenome, the state of genetics is still in it's early conception. Infancy is a long way off.

  • How can someone be tested? My mom has Parkinson's, and I would like to know the risk to me. Thank you for any information you could give me.

  • Your mom can be tested for free by going to the website. They send a saliva-spit-collection kit. You can also get it but its $99. The ultimate test is a Dat scan.

  • When I got my results I was also sent information which shows it is not just one gene variant that they test for but 10 and Im sure there will be more in the future.

    Like many people here my report says that I do not have increased genetic risk for Parkinson’s, However the updated bar graph shows a slightly increased chance over two variants. Currently they say that genetics accounts for only about a quarter of those who get Parkinson’s. It may be due to other factors such as environmental or genes that researchers have not yet discovered.

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