I realise that this sounds a stupid question, but was wondering if anyone has found this to be the case? I have been away in my caravan over the last weekend. When I am there my meds usually last longer, but this time my tremor has been much worse. I don't know if this is because it was extremely cold, though we kept warm, or could be related to just having started on Sinemet CR. I already take Stalevo and Requip daily and Sinemet CR at night I noticed my meds worked really well while on holiday in the Canaries earler in the year when my tremor was hardly noticeable. Maybe I should move there!