i take sinemet 25./100 every 2 hrs and mirapax .25 every 4 hrs both starting at 4 am and the way the meds work are crazy! sometimes they kick in 20 min sometimes an hr 1/2 and every time in between... sometimes when i take a dose it doesn't even work... sometimes back to back doses so for 4 hours i am miserable and can't do anything.... unable to walk/move. other times when i take a dose and i may take a few min early to prevent "wear off" and i feel perfectly fine then about 10 - 20 min later i feel worse before feeling better. no rhyme or reason for any pf this. is it possible to have that nice consistency thruout my days so i can enjoy them bec. this roller coaster ride i am on really sucks and i never know how i will be from min to min. when my meds do work i feel somewhat normal...walking/moving normal sometimes without a cane even. although my balance still may be affected, but not always. does anyone else experience this? what could possibly be making me this way or is it just the way it can be? is it what i eat or my activity? i know protein can affect the way the meds work, but it's kinda hard to avoid an hr or 2 before or after taking meds when i am on a a schedule every 2 hrs. i talk to my dr. about it and he just says that how it is.... welcome to the world of parkinson's.... i hear a lil sarcarism in that statement. every time i bring up something new that's his comment. everything just gets blamed on parkinson's. well, i am going to mayo clinic in december to see if they can offer any other treatment options for me and i am looking for a new neurologist in january. does anyone think it's a good idea for going to mayo clinic? all your thoughts and comments welcome! please help! would also love to hear if anyone has this much trouble with their medications. thank you.