hi everyone, i know everyone responds differently on meds, but i am going to ask anyway. i currently take sinemet and mirapex every 2 hrs and it doesn't seem to work for me very well. i mention to my doc all the time n all he ever does for me is increase the frequency of my doses (which alot of times makes me very dizzy (walk like a drunk) and makes side affects worse. i had also heard if you take too many doses of sinemet in 1 day it could make your symptoms of pd worse, which i feel that way but alot of times unsure if meds or disease itself that make me feel that way. he did have me try comtan n stalevo before n didn't work for me either for one reason or another. anyway after reading some of these posts i thought about asking my doc if i could switch to madopar and the neupro patch. and possibly one tab of a CR (controlled release) to help me to get thru nite bec i cant move around in bed and i always have to get up at least once in middle of nite to use restroom.... that so much fun NOT it is always a challenge and i have to grab ahold of something to pull myself up just to get out of bed. any suggestions please? everything i do anymore is like a chore, everyone's input would be appreciated, thank you!