Last year I suffered from restless leg syndrome for about 7 months.
After seeing my consultant is was agreed that I take 0.088mg of pramipexole (mirapexin) to try and enable me to sleep. It worked. Brilliant. Slept every night since. Saw my consultant the next month and he decided on a program of increasing the dosage. I got up to 0.52mg slow release which I took at night. I noticed that my tremors were getting worse and dyskinesia playing up as well but tried to keep going as per instructions. The program was to increase the tablets by 2 every 2 weeks until I ws taking a maximum of 6. Well, after only 2 nights of 1 x .52mg my life turned into a nightmare. My tremors had gone sky high, dyskinesia in right leg extremely painful culminating in a dystonia attack on my neck which spread into my cranium and I was in agony. Heat pad applied and after about 20 minutes dystonia lessened and eventually stopped leaving me with a slight headache.
I have great faith in my consultant but they don't always get it right. The idea of increasing the mirapexin was to reduce the sinemet I am currently taking. A great idea but just far too quickly.
I, having discussed this with my GP, am going back to basics i.e. 0.088mg which I started on. That way I will hopefully still sleep but not have any adverse effects during the day. I hope this will help anyone else on a similar program.
A side issue - my wife told me she was getting depressed watching how these tabs were affecting me. I was so busy trying to cope that I did not notice. I think it is worth remembering that carers have a hard time as well. I know Elaine feels inadequate at times regards my PD. Frustration is a 2 way street. Sometimes carers are not given the acknowledgement that they deserve.