Protective role of ibuprofen.

[Farooqji]

Taking ibuprofen or aspirin lowered the risk of penetrance of the mutation in the LRRK2 gene, prompting less risk of developing Parkinson's disease. The study suggests that nonsteroidal anti-inflammatory drugs could be a modifiable determinant of LRRK2 penetrance.

journals.lww.com/neurotoday...

[rescuema]

Well... but I'd like to keep my kidneys healthy than taking NSAIDs regularly.

[park_bear]

Important find for those with the LRRK2 mutation.

Abstract at:

onlinelibrary.wiley.com/doi...

Just an association but a very strong association:

" Regular NSAID use was associated with reduced odds of PD in the overall cohort (odds ratio [OR], 0.34;"

Rationale for causation:

" Pharmacologic immunosuppressionand use of NSAIDs in rodent PD models also reduce neurodegeneration, highlighting aberrant neuroinflammation as a viable target for disease modifica-tion in PD."

[jeffreyn]

From iqbal's linked article:

"[Dr. Schwarzschild] cautioned, 'There are risks from regular NSAID use, and I don't think the neurology community can recommend NSAID use even to those who are gene carriers who don't have the disease. Gastrointestinal bleeding can be lethal, and I don't think it is sound medical advice to advise using an NSAID for prevention without further study.'”

But we already have the disease, so the only "prevention" we can hope for is preventing the disease getting worse. But even for this use, Simon urges caution:

"The problem is that over use of ibuprofen can lead to complications, in particular gastric bleeding.

Healthy individuals who take high doses of ibuprofen on a regular basis are 3x more likely to experience gastric bleeding than those who do not take the drug. And significant gastric bleeding can be found in otherwise healthy people as early as three days after starting an ibuprofen regimen.

Thus, long term use of anti-inflammatory medication like ibuprofen is simply not an option."

scienceofparkinsons.com/201...

[park_bear in reply to jeffreyn]

I use the liquid filled gel caps which spread the active ingredient around when they dissolve. The solid pills can end up resting against the stomach lining delivering a concentrated dose to a small area.

[jeffreyn in reply to park_bear]

Are you saying that you are not a long-term user of anti-inflammatory medications, but when you do use ibuprofen, you use the liquid filled gel caps version?

[park_bear in reply to jeffreyn]

That is correct.

There was a time prior to my diagnosis when I used ibuprofen a lot.

[rescuema in reply to jeffreyn]

Not only that, you don't want to end up on dialysis.

"Long-term NSAID use can lead to chronic kidney disease (CKD). In patients without renal diseases, young and without comorbidities, NSAIDs are not greatly harmful. However, because of its dose-dependent effect, caution should be exercised in chronic use, since it increases the risk of developing nephrotoxicity."

ncbi.nlm.nih.gov/pmc/articl...

"NSAIDs can induce several different forms of kidney injury including hemodynamically mediated acute kidney injury (AKI); electrolyte and acid-base disorders; acute interstitial nephritis (AIN), which may be accompanied by the nephrotic syndrome; and papillary necrosis "

uptodate.com/contents/nsaid...

Best to lower inflammation through better diet and exercise, IMO

[Despe in reply to rescuema]

Rescuema, when the pain strikes, one takes Ibuprofen or Aspirin, no time to think about kidneys. My husband takes Aspirin for pain and heart protection. We opted for Baby Aspirin rather than statins after he had carotid artery stenting. However, he doesn't take it daily as he takes natural blood thinners, too.

By the way, yesterday, we both started Lugol's Iodine (2%). I have a couple of drops in filtered water and husband takes 3-4 drops. I was reading about Lugol's Iodine yesterday, fascinating!

[rescuema in reply to Despe]

Occasional use for pain/inflammation should be fine as long as you don't have a kidney condition, but it's the chronic use you need to worry about.

It took you long enough! I remember recommending iodine to you a long while back. Just be sure to supplement selenium while supplementing iodine. Be sure to pulse the dosage, meaning 4-5 days in a row, 2-3 days rest.

[Despe in reply to rescuema]

I hear you. He takes Dr. Dean's ReMyte (minerals which include Selenium) plus he takes minerals intravenously almost once a week to every 10 days at our homeopathic doctor's clinic. He takes all the "companion" vitamins.

Personally, I am experiencing this metallic taste in my mouth (second day today).

Thank you!!

[rescuema in reply to Despe]

You're such an amazing caretaker. Your husband is a lucky man.

[Despe in reply to rescuema]

Thank you. At times, I feel exhausted. . .

[rescuema in reply to Despe]

I hear you. It's no easy task to try slowing the progression and heal as to simply medicate. 👍👍

[CaseyInsights in reply to Despe]

You can rid yourself of the metallic taste of iodine by taking tablets. See here -

optimox.com/iodoral

[Despe in reply to CaseyInsights]

Thank you! I am aware of those tablets. I elected the drops as it is easier for my husband and myself to take the liquid form.

[Somic67]

ibuprofen causes gluthatione and vit. C depletion in the body and is toxic for liver and kidneys.

the quantity create the poison

(even water can kill us)

My opinion is that long term use of any chemical at high (not natural) dosage is likely to create unbalance of the nutrients, generally those needed to metabolize or escrete it.

[pvw2 in reply to Somic67]

What about low dose (baby) aspirin once a day? That's what my doctor recommends.

[Despe in reply to pvw2]

If you take natural blood thinners (fish oil and COQ10, maybe some others) you can take baby aspirin a couple of times a week. That's what we told our Vanderbilt cardiologist and he was fine with that.

[pvw2]

Interesting. Both aspirin and Terazosin increase blood flow and somewhat reduce blood pressure. However the article emphasizes aspirin reducing inflammation.

[Dragona]

Desperate I would be interested to know how the lugols helps please thank you

[Despe]

Please search for "Lugol's Iodine." Here is a link:

jcrowsmarketplace.com/faq.aspx

[jeffreyn]

See also this recent SoPD blog post from Simon:

scienceofparkinsons.com/202...