A groundbreaking study lights up a new way of approaching PD treatment .
" Researchers around the world have tried many ways to generate neurons in the lab, using stem cells and other means, so we can study them better, as well as to use them to replace lost neurons in neurodegenerative diseases," said Fu, who is a Distinguished Professor in the Department of Cellular and Molecular Medicine at UC San Diego School of Medicine. "The fact that we could produce so many neurons in such a relatively easy way came as a big surprise." There are several different ways to mimic Parkinson's disease in mice. In this case, the researchers applied a dopamine look-a-like molecule to poison neurons that produce dopamine. As a result, the mice lose dopamine-producing neurons and develop symptoms similar to Parkinson's disease, such as movement deficiencies.
The treatment works like this: The researchers developed a noninfectious virus that carries an antisense oligonucleotide sequence—an artificial piece of DNA designed to specifically bind the RNA coding for PTB, thus degrading it, preventing it from being translated into a functional protein and stimulating neuron development." Study Notes .
This could lead having more targeted way of PD treatment and to figuring out its basis as still remains unabated .
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