"In 2005, University of California, Berkeley, researchers made the
surprising discovery that making conjoined twins out of young and old
mice—such that they share blood and organs—can rejuvenate tissues and
reverse the signs of aging in the old mice. The finding sparked a flurry
of research into whether a youngster's blood might contain special
proteins or molecules that could serve as a "fountain of youth" for mice
and humans alike.
But a new study by the same team shows that similar age-reversing effects can be achieved by simply diluting the blood plasma of old mice—no young blood needed."
Plasmapheresis could potentially be used to selectively remove aging factors from the blood.
Most PD is age related and rejuvenation therapies could prevent PD or slow progression.
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Rhyothemis
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Very interesting article and already FDA approved and in use! It sounds fairly simple and noninvasive. It seems like a review of patients who have had this procedure would be very enlightening!
Yes, it looks like it could be good, but I try not to get too excited about stuff since there are so many things like this that seem to go nowhere. For example automated driving technology - ten years ago I expected not to have to drive anymore by this time. Around 40,000 people are killed and many more left disabled by traffic accidents each year in the US - one would think automated driving would be a priority. ((shrug))
I need to look up the original research article and see if they have identified the pro-aging factors; there may be ways to downregulate some of them.
Auto driving is coming, replacing workers is very good for business and that's why it was pushed so well by the big private equity and risk capital people...pretty much "turning the corner" (sorry about that) as we speak.
Can your plasma be diluted by donating blood/ plasma and letting your plasma regenerate or would the new plasma contain the same amount of aging factors?
Wouldn’t the young mouse’s organs help cleaning up the blood of the old mouse a bit like dialysis?
Q1: I think that donating blood/plasma would probably have a similar effect. But there are limits to how much you can donate at one time, and how long you must wait between donations. It raises a good question: Do blood/plasma donors tend to live longer?
Q2: I think that the organs of the young mouse may well have been trying to "clean up" the blood of the old mouse, but the experiment showed that the young mouse was still adversely affected by the old blood. Or maybe the organs of the young mouse do not recognize these old proteins as something to be removed?
Regular blood donation might be good for men and non-menstruating women since it can reduce iron overload, but people should probably get their dr.'s okay first.
It's pretty involved; I hope Life Extension Advocacy Foundation does one of their 'journal club' video reviews on it.
"The above concept fits well with the age-imposed increase in systemic
TGF-beta family ligands (GDF11 and TGF-beta 1, for example), which
contributes to pro-geronic phenotypes [7, 14, 1544–47] and the fact
that attenuation of TGF-beta signaling in old animals has effects
that are similar to those of NBE [7, 14, 15, 28, 44]. NBE is also
predicted to promote stronger rejuvenation than an Alk5 inhibitor, as
that attenuates just one branch of one pathway, and because proteins
other than the TGF-beta family that are elevated with age will be
re-set to their younger levels of gene expression and/or signaling
intensities by NBE/TPE (to be profiled in the future). Fitting the
model that is shown in Figure 6 with experimental data on multiple
time points after NBE/TPE, for multiple proteins and multiple levels
of regulation (mRNA, protein, signaling intensities), is a focus of
our long-term work.
One thing that occurs to me is that the dilution will probably stimulate production of erythropoietin (EPO) [I think it did but I'm not sure I'm interpreting the figures correctly] and that will have effects on iron homeostatis. The authors mention EPO -
"an increase in erythropoietin is likely to improve the numbers and health of erythrocytes, attenuating age-imposed anemia" - I think that statement rather short-sells the effects of EPO.
In the interview they say that clinical trials are planned for fibrotic diseases, inflammatory diseases, and type 2 diabetes or associated metabolic diseases.
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