Parkinson's dyskinesia mechanism explained

[Buckholt]

New hope for a therapy to control dyskinesia, study suggests.

eurekalert.org/pub_releases...

[MarionP]

Risking potential of lupus or lymphoma...they might have forgotten to mention it. Or maybe they are thinking the same thing that interferes with some anti-cancer t cells also stimulates abnormal or erratic growth in vessel cells including erratic or signal-without-a-home-or-function\uncoordinated motor signals...? Interfering with motor neurons that use some of the same neurotransmitter, dopamine? Interesting. Maybe very brilliant too.

[sharoncrayn in reply to MarionP]

Did they check with their mice? If they could only talk.

[sharoncrayn in reply to sharoncrayn]

"Our findings showed that RasGRP1 deleted mice (RasGRP1−/−) had drastically diminished L-DOPA-induced dyskinesia, " The mice were saved from dyskinesia. Now, if we can only delete RasGRP1 in humans without turning them into zombies.

[sharoncrayn in reply to sharoncrayn]

Of course, we could also conclude without consulting the mice that "evidence has accumulated to indicate that dopamine replacement therapy, whether pharmacological or cell-based, cannot reset the striatum back to its normal physiological state but introduces novel functional/dysfunctional states that strictly correlate with the profile of treatment-induced motor effects."

"cannot reset the striatum back" is obviously a critical issue regardless of what the mice would say.

Sharon

[MarionP in reply to sharoncrayn]

If only they could talk, indeed! Assuming their squeaker motor neurons were relieved of their TD.

No going back, yes. Which also means you can't do experimental reversals. But at least they might get a myeloma over time. It really is inconvenient, the body using the same substances for different purposes. But then, otherwise we might need to evolve six hands or something else. After all, we've only been around so for so long.

By the way, it occurs to me that computers use somewhat similar signalling and can develop similar problems using just electrons for signalling. Over time their circuits develop little electron fingers that eventually jump their insulators and join up with other circuits sideways, and short them out. Substitute "potential changes" as a local change in charge and maybe that is like neurons developing static shorts in the same way that the authors described as additional lateral growth stimulated by RasGRP1 sideways from the signalling pathway direction, would be the equivalent of "static" and "shorts" in computer signal path and maybe source of additional dyskenesia in that way, that's how I visualize it anyway. I wonder if the analogy really holds that way.

[sharoncrayn in reply to MarionP]

In the real world where a few of us live, people should spend more time ingesting liposomal vitamin C (2 grams liposomal Q6hrs if potentially infected) . Without sufficient levels of vitamin C (way above the typical scurvy level found in many PD patients), you can't start the Tyrosine to L-dopa to Dopamine pathway which ultimately leads to the creation of vassopressors. IOW, tyrosine hydroxylase needs Vitamin C.

Is chelated zinc relevant in treating sepsis and PD? Yes if it can get into the intra-cellular space.

Critical question: Is septic shock related to covid-19 and PD?

Yes, in some respects. The mice told me so. So brew up a cocktail of specific vitamins and minerals before heading down the rabbit hole of microbiology where the mice hang out. It may save you a trip to the ICU.

[MarionP in reply to sharoncrayn]

liposomal vitamin C Thanks, I will look up how to get this particular. Was new to me, had no idea you could get it fat soluble.

[sharoncrayn in reply to MarionP]

Get it only in gel form or liquid with sunflower (no soy). I don't believe it is truly liposomal in powder or tablet, but some mfgs. would disagree. Liposomal C is not "tasty".

[MarionP in reply to sharoncrayn]

"The mice told me so."

"Yes, thank you, Slartibartfast, that will be all..." A good one of many from that guy. I have referred to our current leader as President Zaphod (who once said the actual job of the President is to divert attention from the real power) more than once.

[sharoncrayn in reply to MarionP]

Zaphod is fictional, but who cares.

Trump is sort of the donkey everyone wants to pin the tail on; no one discusses Xi Jinping nor doctor "bat woman" who cooked up this mess in her kitchen lab in the class 4 virology lab while doing work for the CPC's Humane Society for the Preservation of Chinese Bats. What a sweat heart!

Fascinating how MSM dictates most people's thinking. Actually, scary.

Sharon

[sharoncrayn in reply to sharoncrayn]

Not sweat heart but sweet heart.

[MarionP in reply to sharoncrayn]

Whoa....more about this bat woman please, all news to me.

[sharoncrayn in reply to MarionP]

Batwoman is an old, old story to my virology friends, and it is beginning to leak out via UK's intel and SoS Pompeo.

The Wuhan Institute of Virology - (a class 4 bio weapons factory) which was conducting controversial experiments into animal-to-human transmission of bat and other animal coronaviruses, altered their database in an apparent attempt to distance the lab from the outbreak.

According to the Washington Post: "Days before the Wuhan wet market was bleached, whistleblowers were punished and virus samples were destroyed, someone at the high-security Wuhan Institute of Virology censored its virus database in an apparent attempt to disassociate the laboratory from a novel-coronavirus outbreak that would become a global pandemic,"

Notably, the alteration occurred two days before a gene sequencing lab was reportedly ordered by the CCP's CDC to destroy samples of the new disease, the gene sequencing and withhold all other information.

The culprit in the creation of this toxic virus was Dr. (Ph.D.) Shi Zhengli - known as "batwoman" for her controversial experiments, including the creation of a several 'chimeric' (animal) coronaviruses that can infect humans without any known treatment. Director of Wuhan's lab she became world famous in 2013 claiming bat feces were 96% equivalent to Sars-cov-2.

Her admonitions of innocence ring hollow since she published her studies with the bat virus RaTG13, a very close relative to SARS-cov-2. Add in the fact that a young ophthal­mologist, Dr. Li Wenliang, the initial Chinese whistle blower, died mysteriously of covid-19 after linking her and the lab to the virus outbreak.

Did she release, or others, the virus deliberately? University of Texas at Galveston set up the Wuhan lab for the Chinese, but they didn't supervise their internal safety protocols.

I assume the release wasn't deliberate, but she definitely wiped the databases clean to protect herself from possibly ending up with Dr. Li.

She is now missing. DOA? So long Mommy Dearest.

Sharon

[sharoncrayn in reply to MarionP]

Before the virus pandemic, we had 4 super star "toxic" bio engineered type virologists/immunologists: 1) Dr. Plummer at Canada's NML class 4 ( since assassinated), 2) Dr. BatWoman now DOA or missing , Director of Wuhan's class 4 lab, 3) Dr. Bavari who is an immunologist but Director of USAMRIID (infectious diseases and virus development for the military), and 4) Dr.Peter Piot of the UK, a virologist who discovered the Ebola virus and is very buddy-buddy with the Fauci/Birx/Redfield because they are all knee deep in HIV.

Fauci is an internal medicine doctor as is Birx and Redfield but long time involvement with HIV-AIDS for all of them...none of them have research credentials.

Bright, formerly of BARDA, is an immunologist without any research credentials.