Xadago to take with Kinson

[TL500]

Has anyone have experience with taking Xadago with Kinson 100/25 please?

According to my doctor it's like Azilect but stronger and more effective.

Any thoughts please? Like benefits verses side effect?

I am hesitant to add any more drugs to my regime. I prefer taking supplements instead.

Thanks.

[park_bear]

Xadago is an MAO-B inhibitor and should be synergistic with Kinson. I have not seen any reports of serious adverse effects. I would not be afraid of this one, although do be aware of potential interactions drugs.com/drug-interactions...

[TL500 in reply to park_bear]

Thanks very much park_bear.

[jeffmayer]

I have been taking it for two years with sinemet I can only say it has had a positive effect

[TL500 in reply to jeffmayer]

Thanks jeffmayer. Sounds like it's good.

Do you have any side effects from both meds?

I experience, I think, like I saw in HU a few people have dystonia side effect from Sinemet/Levadopa/Kinson etc. After taking Kinson for between 2-4 hours, my body feels like strong pulling to one side or forwards and stiffen up/freeze... I'm scared and hate this when it happens.

I'm on Kinson so dr asked if I wanted to change to other meds like Levadopa etc. because of side effect. I refused so he suggested to add Xadago to Kinson.

I cut down from 3 to 2 Kinson per day and take a lot of supplements. He wants me to take 3, but I insisted 2 so he was ok with it. He said to take 1 Xadago on top to smooth out the effect of dopamine available and hopefully cut out the undesirable side effect of Kinson.

I'm reluctant to take more meds, especially one that is new on market like this one.

Please see my reply to Joynb below and tell me what you think. Thanks.

[jeffmayer in reply to TL500]

Dyskinesia which is a pain in the arse you can take amantadine but the list of side effects is a mile long

[TL500 in reply to jeffmayer]

So my side effect is dystonia or dyskinesia?

Do you take amantadine too?

Thanks

[jeffmayer in reply to TL500]

I was supposed to but I sacked it off cos of the side effects each to his own good luck

[jeffmayer in reply to TL500]

But I would recommend this not done me any harm the dyskinesia is caused by sinemet

[TL500 in reply to jeffmayer]

You mean Xadago not done you any harm?

Thanks Jeff.

[jeffmayer in reply to TL500]

Yes sorry

[TL500 in reply to jeffmayer]

Thanks Jeff

[TL500 in reply to jeffmayer]

Jeff, did your dr suggest xadago because of dyskinesia from sinemet side effect same as me?

[jeffmayer in reply to TL500]

no apparently it supports the Sinemet according to my pd nurse

[Joynb]

I have been taking it for a few months with Stalevo. It has greatly improved my response to Stalevo. My stability is so much improved that I have been able to get my drivers license back.

[TL500 in reply to Joynb]

Joy, did your dr suggest xadago because of dyskinesia from Stalevo side effect same as me?

[TL500 in reply to Joynb]

Sounds very good. Thanks Joynb. Only thing is, maybe I'm dreaming, but I aim towards getting better so can reducing/coming off meds, let alone adding more...

My dr said Xadago uses our own dopamine by, I think, blocking an enzyme or something that clears dopamine(?) so that our dopamine stay (?). Sorry, not sure if I got it right? Anyway, I like the fact that it uses our own dopamines. However, if, like what I think he said will the enzymes get blocked/cut permanently? and when we come off meds the brain won't function normal? Please share what do you think re this? Thanks.

[Joynb]

Xadago made it possible for me to reduce stalevo by 30%. Going drug free with PD, sorry to say, is not a realistic goal. Slowing the increase in medication can be realistic- exercise, life style adjustments, relaxation all help, so does xadago.

[Joynb]

On the permanency angle, all sorts of things on the PD brain are stuffed permanently. I choose to go with the things that help me function well now. Who knows if I will be around tomorrow, today is what counts. That’s my outlook anyway, yours may we’ll be different.

[Joynb]

My doctor was interested in dyskinesia levels but main goal was better control without further increase in drug levels.

[TL500 in reply to Joynb]

Thanks Joy for all the valuable info and thoughts. Appreciate.

[jaycees]

I am a bit late to the party but hope you'll find my comments of some use. I have been switched from Azilect to Xadago almost 12 months ago and have been feeling that Xadago seems to produce a longer and smoother transition at end of dose than Azilect. I take Stalevo (levodopa/carbidopa/entacapone) 75mg 4x/day plus Sifrol ER (pramipexole) 1.25mg 1 a day. The only thing is Xadago was supposed to reduce dyskinesia hence the switch but it's not doing that for me. Dyskinesia is definitely present after 14 years of taking levodopa! My doc then added Symmtrel (an amantadine) to try to control it. The jury is still out on this last one but in short, my experience with Xadago is good so far.

[TL500 in reply to jaycees]

Thank Jaycees for the valuable info. How long did you start to get dyskinesia from levodopa?

Is 75mg Levodopa/carbidopa 3/4 of a tablet of 100/25?

So you took Azilect with Levodopa these 14 years?

Are there different strength of Xadago?

And do you know what is the difference between Azilect and Xadago?

Is it new on the market?

Thanks.

[jaycees in reply to TL500]

To answer your questions:

I noticed the extra body movements after about 8 years on levodopa, I think.

I don't know if you can equate one drug with another as they may have different ingredients and formulation. It's better to check with your doctor, but conceptually yes, although the Stalevo does come in 75mg so I never have to try to break it up. In fact, my pharmacist would be horrified if I do that!

In the beginning, I was prescribed Madopar (levodopa) followed by Sifrol. They worked fine for a few years then freezing started and became so bad Madopar was replaced by Stalevo and later, Azilect was added to reduce the end of dose dip which made me susceptible to freezing. That helped but it didn't stop other types of freezing triggered by stress or anxiety, I haven't found anything that would stop all freezing. I also note that I started having falls couple of months after taking Azilect, although I can't conclusively say Azilect was the cause. Anyway, Xadage was introduced last year in place of Azilect to try to curb dyskinesia which is now prominent.

Xadago comes in 50mg and 100mg tablets, not sure if it goes higher. It is newer than Azilect. For their differences you're best to read the drug information sheets or ask your doc.

[TL500 in reply to jaycees]

Thanks jaycees. Have you tried HDT? I think it helps or supposed to help with the dyskinesia.

[jaycees in reply to TL500]

No, I don't know anything about that I'm afraid. Does it work?