Madopar and sinimet

[nourilo]

Are Madopar and Sinimet interchangeable?

[sharoncrayn]

These 2 drugs are absolutely NOT similar in chemical structure although both contain levodopa. Nor are they similar in available doses. Modopar has 2 dose combinations; sinemet has 3 plus a controlled release formulation.

Are they interchangeable? Some who have used both say yes; some say no.

Sharon

[condor39]

They both contain levodopa, and should be equivalent, but I got GI problems with Sinemet, and not with Madopar, (Actually I take the Canadian version, called Prolopa, which is in capsule form, and has two strengths, 25/100 and 50/200. The Movement disorder clinic I attend, suggested not using the higher dose capsule due to “Absorption problems”) I started with a slow dose and slowly increased until it took effect.

[nourilo in reply to condor39]

Thanks that was informative

[sharoncrayn in reply to condor39]

They aren't equivalent drugs. Never meant to be. Two different approaches in attempting to force more levodopa out of the PNS into the primary CNS.

Sharon