Levodopa: Molecular Effects of L-dopa The... - Cure Parkinson's

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Levodopa: Molecular Effects of L-dopa Therapy in Parkinson's Disease.

aspergerian profile image
21 Replies

Molecular Effects of L-dopa Therapy in Parkinson's Disease.

2014.

ncbi.nlm.nih.gov/pubmed/246...

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aspergerian
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aspergerian profile image
aspergerian

Protective Effects of Crude Plant Extracts against Aminochrome-induced toxicity in Human Astrocytoma Cells: Implications for Parkinson's Disease.

2019.

ncbi.nlm.nih.gov/pubmed/313...

MBAnderson profile image
MBAnderson

How many neurologist prescribe nutritional components (B6, B12 and folate) to compensate for the oxidative stress, inflammatory factors, reduced glutathione, etc caused by long-term use?

drugs.com/sfx/levodopa-side...

role of nutrition

ncbi.nlm.nih.gov/pmc/articl...

17 Action Steps to Improve Parkinson’s Disease

drjockers.com/improve-parki...

The Parkinson’s disease death rate: carbidopa and vitamin B6

"During the first 15 years of prescribing L-dopa, a decreasing Parkinson’s disease death rate was observed. Then, in 1976, 1 year after US Food and Drug Administration approved the original L-dopa/carbidopa combination drug, the Parkinson’s disease death rate started increasing. This trend has continued to the present, for 38 years and counting. "

ncbi.nlm.nih.gov/pmc/articl...

AmyLindy profile image
AmyLindy in reply to MBAnderson

These are great references- thanks- saving to my arsenal. The nutrition article is consistent w/my working knowledge which is comforting & adds layers of validation. Must save for later. How do you organize your PD Arsenal? I was saving as .pdf to a “PD folder” w some various subtitles on Dropbox, ran out of space and started saving to iBook when it pops up and / or iCloud as a document. I’m starting to save everything “compulsively” but need to take a time out to sort /build a system. You seem Uber organized w/links and clear communications- I assume you’ve figured out an excellent filing system already? The new iMac has me curious about iCloud and Desktop- I truly need an admin day to create my best system. Using/reading on iPhone is lazy & leaves you subject to rotating / or random “save” options (it seems).

MBAnderson profile image
MBAnderson in reply to AmyLindy

I have a fairly articulate filing system. Nothing special, though. I file stuff by subject. The trick is how you label the file.

I've been using Windows 7, but it is no longer going to be supported after January 14, so I have to decide between Windows 10 and a chrome book. I just got a chrome book Saturday, although I'm not certain I'm going to keep it. The extra security and working out of the cloud intrigues me. I am a little concerned about how frustrating it might be to learn the OS system.

AmyLindy profile image
AmyLindy in reply to MBAnderson

It’s frustrating when stuff is piling up while you’re trying to simultaneously figure it out- for sure!

aspergerian profile image
aspergerian in reply to AmyLindy

Try zotero.

zotero.org/

AmyLindy profile image
AmyLindy in reply to aspergerian

Thx will peek at it!

MBAnderson profile image
MBAnderson in reply to AmyLindy

PS. I only file links. I don't file the content/pages.

AmyLindy profile image
AmyLindy in reply to MBAnderson

Great way to save space !

Rosenmu profile image
Rosenmu in reply to MBAnderson

"L-dopa active ingredient products may be administered as a nutritional supplement or a drug. Nutritional supplements are generally recognized as safe (GRAS), allowing over-the-counter sales.12 Due to side effects, carbidopa is not GRAS.3 It may induce life-threatening events including myocardial infarction, neuroleptic malignant syndrome, agranulocytosis, hemolytic and nonhemolytic anemia, gastrointestinal bleeding, thrombocytopenia, and hypokalemia While carbidopa side effects require its discontinuation when the continuation of L-dopa is indicated, nutrient products are the only option. Most physicians are unaware of the availability of this L-dopa form."

Fortunately, my doctor put me on Mucuna and watches my glutathione levels closely.

to67 profile image
to67 in reply to MBAnderson

We have a Patented Technology that is made from your mitochondria. It Increases blood flow 55% so it's reducing inflammation and pain. It's proven to increase your own antioxidant production upwards of 500%. Glutathione is your master detoxifier, right? 500% production!!

Is it helping, Yes!

Farooqji profile image
Farooqji in reply to to67

Please share the link to your patented technology via PM

JANVAN profile image
JANVAN in reply to Farooqji

and iqbaliqbal : >>> received anything ??

ConnieD profile image
ConnieD in reply to to67

I would be very interested too, thank you!

MBAnderson profile image
MBAnderson in reply to to67

Please send me your info via private message.

JANVAN profile image
JANVAN in reply to MBAnderson

and Marc >>> received anything ??

MBAnderson profile image
MBAnderson in reply to JANVAN

I got this message. I didn't call. It is clearly phony.

"Hello there, My name is ...

Since we're 10 yrs old, there's lots that has been proven. I would appreciate the chance to talk first, so I can explain our Patented Technology. I only need 5 min.

Then, I can't wait to send you our Patented Science to review. It will help you and it's not another drug!!

Would you kindly call me and then I can get your email so I can send you our amazing information.

Kindly~

"

aspergerian profile image
aspergerian

94 cite Krajcovicova 2011: The default mode network integrity in patients with Parkinson's disease is levodopa equivalent dose-dependent.

scholar.google.com/scholar?...

aspergerian profile image
aspergerian in reply to aspergerian

Dysfunction of the Default Mode Network in Parkinson Disease.

A Functional Magnetic Resonance Imaging Study.

ncbi.nlm.nih.gov/pmc/articl...

113 cite Delaveau 2010: Dopaminergic modulation of the default mode network in Parkinson's disease.

scholar.google.com/scholar?...

Dysfunction of the Default Mode Network in Drug-Naïve Parkinson’s Disease with Mild Cognitive Impairments: A Resting-State fMRI Study. 2016.

ncbi.nlm.nih.gov/pmc/articl...

aspergerian profile image
aspergerian

Also:

Pathophysiology of L-dopa-induced motor and non-motor complications in Parkinson's disease.

2015.

ncbi.nlm.nih.gov/pubmed/262...

And:

ncbi.nlm.nih.gov/pubmed/315...

ncbi.nlm.nih.gov/pubmed/308...

Regulation of dopamine neurotransmission from serotonergic neurons by ectopic expression of the dopamine D2 autoreceptor blocks levodopa-induced dyskinesia.

ncbi.nlm.nih.gov/pubmed/306...

aspergerian profile image
aspergerian

Levodopa dyskinesia miscellany.

ncbi.nlm.nih.gov/pubmed?lin...

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