Does Magnesium, especially L-Threonate cancels out levadopa effect?

[TL500]

Hi, My PD friend has leg / foot cramp and I suggested Magnesium, but she said it cancels out levodopa (c/l).

Any suggestion please? Thanks.

[park_bear]

I spray on magnesium chloride. In my experience does not interact with levodopa.

[TL500 in reply to park_bear]

Thanks

[JBOVERT in reply to park_bear]

Hi Park So you said you "spray" it on where do you get that spray and where do you spray it? jim

[park_bear in reply to JBOVERT]

Cheapest way is to dissolve magnesium chloride in water and put in spay bottle.

[JBOVERT in reply to park_bear]

ok now here do you spray it?

[park_bear in reply to JBOVERT]

on tight muscles

[JBOVERT in reply to park_bear]

IS THIS an amazon product or where is the best place to buy it...is it good for cramps?

[park_bear in reply to JBOVERT]

Yes and yes

[JBOVERT in reply to park_bear]

THANK YOU SO MUCH PARK YOU ARE SO HELPFUL

[chartist in reply to JBOVERT]

JBOVERT,

This link will answer all of your questions about Mag Oil (MO) Including how to make it less expensively than the commercial products if you like the way it works for you :

healthunlocked.com/cure-par...

Art

[JBOVERT in reply to chartist]

WOW ART THANKS VERY MUCH FOR ALL THAT INFORMATIONAPPRECIATE IT VERY MUCH - JIM

[chartist in reply to JBOVERT]

Jim,

I hope it helps you if you try it! If you do try it, please share your results with the forum as that may help someone else who is considering trying it.

Art

[PDConscience]

Anecdotal chat (with a pharmacist):

“The one thing i can state with certainty is that magnesium does interact with Sinemet and it's generic product (carbidopa/levodopa). That interaction is that some antacids that contain Magnesium, Aluminium, or Calcium may increase the absorption of levodopa. The reason or mechanism to this interaction may be related to the increase of gastric Ph and/or decrease in gastric emptying time which would result in the breaking down of levodopa. All of this would result in more levodopa being absorbed from the small intestinal a greater amount being available in the blood. This may result in the dosage of levodopa having to be adjusted.”

Source: forum.parkinson.org/topic/2...

[LAJ12345 in reply to PDConscience]

That link also says that it is ok to take the magnesium so long as gap of 2 hours is given between them

[PDConscience in reply to LAJ12345]

If it enhances levodopa’s availability when taken together (requiring a lesser dosage), why would you want to interfere? Unless, of course, the referred increase in the “absorption of levodopa” takes place BEFORE crossing the BBB...

[LAJ12345 in reply to PDConscience]

This actually sounds like nonsense doesn’t it? More is broken down so more is absorbed? I don’t understand that.

[TL500 in reply to LAJ12345]

That's what I do. Thanks

[TL500 in reply to PDConscience]

Thanks

[MehmetKutlu]

Mg-T is excellent for sleep.

[TL500 in reply to MehmetKutlu]

Thanks

[jujulini]

I understand that the L-theonate form of magnesium does not cause diarrhea. I have been taking it at night for the past couple of months for insomnia and have been sleeping much better.

[TL500 in reply to jujulini]

sounds good. Thanks

[Smittybear7 in reply to jujulini]

Thanks

[Idofotos]

I take a 400 mg capsule at night at bedtime no more leg cramps

[TL500 in reply to Idofotos]

Thanks. Which brand are you taking please? Thanks.

[Idofotos in reply to TL500]

Nature made

[TL500 in reply to Idofotos]

Thanks

[KERRINGTON in reply to Idofotos]

I take 3 capsules Life Extension Magnesium L Theonate 4 x a week...no leg, toe, or finger cramps.

[Stazina]

Magnesium occurs naturally in the body and is essential for life. It regulates muscles, nerves, blood pressure and blood pressure. L -Theanine is a non protein amino acid, it increases GABA and Dopamine. This is found in green tea and black tea. Your friend is misinformed.

[TL500 in reply to Stazina]

Thanks Stazina. Which brand do you think/experience with is better? and how much per day?

[Stazina in reply to TL500]

I think the first step is for your friend to ask for blood work to find out if she/he is Magnesium deficient; however from ages 31-51+ 420 mg daily for males and 320 mg daily for women is the Recommended daily allowance. Eating foods rich in Mg is important i.e...leafy green vegetables and legumes. There are a lot of different Magnesium supplements but Magnesium Gluconate is shown to have the highest absorption rate but has a laxative effect. Magnesium Glycinate is probably your best bet as it absorbs well and has less of a laxative effect.

[TL500 in reply to Stazina]

Thanks. But isn't L-Threonate is what we need for the brain for PD, AD etc?

[Stazina in reply to TL500]

Based on this study ncbi.nim.gov there's a theory that Mg deficiency is involved in the formation of Parkinsonism-Dementia complex by decreasing the lack of blood flow to the brain in rats. Mg-L-Threonate can carry the Mg through intestinal wall to the blood stream and the through the blood brain barrier. My opinion is the bottom line is that is important to find out what nutrients your body is deficient in and correct it. If your not body is not low on Mg, taking more is not going to help heal anything.

[TL500 in reply to Stazina]

Thanks Stanzina. According to Dr Carolyn Dean about her Magnesium reasearch, her list of most people with Magnesium deficiency also has people with PD, AD etc.