Many places it is written to avoid taking C/L with food. I think this to avoid the C/L absorption problems when the meal contain protein, and also, I guess if you take the C/L immediately after a large meal, it could be a while before the C/L reaches the small colon (where it can be absorbed)...
But I also see this:
rxlist.com/sinemet-cr-drug.htm
"The extent of availability and peak concentrations of levodopa after a single dose of SINEMET CR 50200 increased by about 50% and 25%, respectively, when administered with food."
This suggests to me that the may be a benefit to taking controlled release C/L with a small amount of food as long as is doesn't contain protein...
And a possible explanation for his may be that when there is food present, there is more acid/enzymes present in the stomach to break down the controlled release tablet more quickly and thus free up more of the C/L (p.s. I know next to nothing about how the stomach works)...
Any thoughts on this?