C/L CR with food?

Many places it is written to avoid taking C/L with food. I think this to avoid the C/L absorption problems when the meal contain protein, and also, I guess if you take the C/L immediately after a large meal, it could be a while before the C/L reaches the small colon (where it can be absorbed)...

But I also see this:

rxlist.com/sinemet-cr-drug.htm

"The extent of availability and peak concentrations of levodopa after a single dose of SINEMET CR 50200 increased by about 50% and 25%, respectively, when administered with food."

This suggests to me that the may be a benefit to taking controlled release C/L with a small amount of food as long as is doesn't contain protein...

And a possible explanation for his may be that when there is food present, there is more acid/enzymes present in the stomach to break down the controlled release tablet more quickly and thus free up more of the C/L (p.s. I know next to nothing about how the stomach works)...

Any thoughts on this?

[buzbyc]

Personal experience (nearly five yrs post diagnosis and only taking Sinemet CR) is that food negatively interacts with how effective I notice it working. I'd also read that research before but can't agree with it in my own personal experience.

[Goldencbc]

I take c/l controlled release with food and don’t notice a difference in how well it works. I have no nausea if I take it with food. I have seen a few others report the same thing. I may have been so nauseated (which was awful) that I couldn’t notice any improvement. LOL.

[cabbagecottage]

The controlled release was given to my husband at bedtime to see him through . .

I believe it can be taken with food .