Glutathione

[Cindyross]

Has anyone heard of Glutathione and are they using it just wondering since my friend has Pd and this is what her naturopath said to take and she said it seems to work

[jimcaster]

I take glutathione supplement. It's a powerful antioxidant. Search this site or Google it and you will learn a lot about glutathione and Parkinson's disease.

[TL500 in reply to jimcaster]

Can you share your experience with it? Thanks

[jimcaster in reply to TL500]

I have no idea what helps and what doesn't, but I'm trying anything which appears helpful and has little or no side effects. So far, I dare say I'm better now than when diagnosed in May, 2018.

[TL500 in reply to jimcaster]

Thanks jim. What brand & name of product?

And your other supplements?

Do you take them at the same time or space them apart?

Thanks.

[jimcaster in reply to TL500]

I take many supplements, but they are listed on my profile. Many, including the glutathione, are from Apex Energetics.

[Toogood in reply to jimcaster]

In what way did it help you please...

[jimcaster in reply to Toogood]

I have no idea what helps and what doesn't, but I'm trying anything which appears helpful and has little or no side effects. So far, I dare say I'm better now than when diagnosed in May, 2018.

[rebtar]

Laurie Mischley, a naturopath who specializes in Parkinson's, recommends glutathione. She has done a study with some 2000 PD patients over the past 6 or 8 years, in which glutathione was one of a few supplements that was associated with slower progression. It's a good one to take, although that doesn't necessarily mean it will result in less severe symptoms. Hopefully it contribuites to slowing progression.

[T-Writer in reply to rebtar]

I have seen a naturopath at Dr. Mischley's clinic and have been taking glutathione for a couple of years now. For me, it definitely reduces dyskinesia from l-dopa meds (generic Sinemet); if I miss a few doses of glutathione I get 'the wobbles' much more than when I am taking it as I should.

I take 600 mg/day, as a 200-mg capsule taken 3x a day, about every 6 hrs while I am awake. The OTC brand I get at a local store is Xymogen, labeled as S-Acetyl Glutathione. A bottle of 60 capsules is about $60.

That may seem like a lot but it is about half (or less) the cost of compounded glutathione nasal spray that's the same as Dr. Mischley used in her studies. I started out on the nasal spray and actually do better on the capsules; the spray didn't spread out the effect of each dose and made me feel 'wound up' (apparently not uncommon).

IMPORTANT: Be sure to get the >>S-ACETYL GLUTATHIONE<< form, not just plain glutathione. Some research online will explain why this matters; I just want to be clear about the oral form that works.

A note about Xymogen: You can't buy from them directly, you have to find somebody they supply who's local to you.

[PDGal4 in reply to T-Writer]

Thank you for your post. Most helpful. Going to look into this.

[pdkid in reply to T-Writer]

thanks for the info! is there a difference in taking s-acetyl glutathione vs. liposomal glutathione?

[Smittybear7 in reply to T-Writer]

I took 30 IVs of glutathione back in 2018. I think it helps overall for your health. It was expensive.

[Parkie-]

WebMD info worth mentioning:

webmd.com/vitamins-and-supp...

"Taking glutathione by mouth does not appear to be an effective way to get it into your body. In one study, giving healthy people 500 milligrams twice a day for a month didn't raise the level of glutathione in their blood.

Some other studies looking at its health effects have used it in injection form or as a treatment inhaled into the lungs."

[T-Writer in reply to Parkie-]

IMPORTANT CLARIFICATION: Although oral forms of plain glutathione don't get into brain cells properly (for complex reasons having to do with how it is transported within the body), the >>S-acetyl<< form of glutathione [that is, S-acetyl glutathione] is a fairly new oral form that

works around these reasons and DOES let glutathione get into brain cells properly, so it can do good things there.

I have taken 600 mg/day of oral S-acetyl glutathione (a 200-mg capsule 3x day) for a couple of years now and it helps a lot to reduce dyskinesia from l-dopa meds (e.g., Sinemet).

[Parkie- in reply to T-Writer]

Yes. That makes sense.

[TSonmez in reply to T-Writer]

Were you able to reduce the amount of sinimet you take daily?

Or does the S-acetyl glutathione actually reduce the dyskinesia. My mom gets it very extreme all day long for the l-dopa.

I am considering taking her to get glutathione infusions.

[T-Writer in reply to TSonmez]

For me the glutathione reduces the dyskinesia with sinemet at the same level, but your mom may need less sinemet or to have it given in different-sized doses and/or at a different interval -- for me dyskinesia happens at the peak of my dose sometimes but ALWAYS as a dose of sinemet is coming on or wearing off (not the usual pattern for most pepple). Seems to me there should be SOME time during the dose when it is 'just right' and she has symptoms controlled but no dyskinesia. Hope this helps and best wishes to her and you.

[pdkid in reply to T-Writer]

is it ok to take glutathione with food? with sinemet? with b1? so many supplements and trying to reduce as much interactions and increase as much synergy as possible! thank you!

[Rwesol]

Yes!! It's a little pricey (best deal 3x $49+shipping= @$156) gets you 1 month, 1m 3x per day. Nanoceutical, Nano Glutathione, Sublingual. Shake well! Best!

[Brills3]

Do you really see a difference in how you move and how you feel...how does it effect you? Thanks!

[Patman60]

I take glutathione injections daily. Bit of a sting but much more effective than oral. Cost about $50 per month. Going on 2 months now. Blood test in few weeks will measure bio markers. As to antidotal evidence of benefits hard to quantify as I have a complex multi faceted 50 + regiment. But feeling more energized an focused and no Levo dopa or precursors

[Zardoz in reply to Patman60]

Daily glutathione injections for less than $2/day? Is this through a doctor or are you a medial professional who can do it on your own?

[Patman60 in reply to Zardoz]

My doctor prescribes and I do self injections

[philipstar]

Hi yes I think your friends naturopath is onto something. Glutathione is a very powerful antioxidant and good for the liver and cleansing and I find that it also helps with my Parkinson's by reducing the tremors. It is not an easy a product to get hold of and I get my from a product I get in the USA, called GRS Ultra and I think I am right in saying that this is not produced as such and is derived from N Acetyl Cisteine (NAC). I have also found that this NAC plus something else called Acetyl l Carnitine are good news for the brains mitochondria and energy levels generally. Very nearly out of my depth as I am not an expert in these matters but think this is roughly right.

[AaronS]

Your body produces glutathione in its purest form, it's likened to being a Master antioxidant, NAC, and milk thistle boost production. Don't buy it make your body produce it. Worked well for me when I was doing this

[Mondoug in reply to AaronS]

I am really interested in how to help my body develop its own “glutathione”!

[Hidden in reply to Mondoug]

Follow John Pepper’s walking protocol and it might help. Although, John claims that the walking improves GDNF/BDNF, it should also probably help produce glutathione.

[Artsue]

I have been taking a precursor of glutathione in the form of a product called Immunocal (look it up online) for more than 30 years. I was diagnosed with PD 4 years ago and feel the Immunocal has been part of the success I've had with very easily managed symptoms. That along with daily vigorous exercise, Carbidopa levodopa (3pills per day), and Azilect is keeping me going.