Overmethylation and Undermethylation: Case Study

[Kia17]

This case study shows how fast methylation can become imbalanced – and how fast it can be rebalanced.

mthfr.net/overmethylation-a...

The Common Symptoms of Overmethylation in Patients

mensahmedical.com/common-sy...

Common Symptoms of Undermethylation or Histadelia

mensahmedical.com/common-sy...

Treating Methylation: Are We Over-supplementing?

kresserinstitute.com/treati...

Like many nutrients, methylation appears to follow a U-shaped curve, where both deficiency and excess cause pathology. While hypomethylation is associated with many different problems, hypermethylation may be equally problematic. What we really need is methylation balance.

Alleviate nutrient deficiencies

Nutrient deficiency is one of the primary causes of impaired methylation. The two most important nutrients in methylation pathways are B12 and folate, but other nutrients such as methionine, cysteine, taurine, DHA, zinc, magnesium, potassium, riboflavin, niacin, pyridoxine, betaine, choline, and sulfur also play a role (10). Inadequate intake of any of these nutrients can impair methylation. Foods high in these methylation-supporting nutrients include beets, spinach, mushrooms, eggs, organ meats, and shellfish.

Support gut health

You might be surprised to hear that bacteria play a role in the methylation cycle. Many Bifidobacteria are folate producers (11), while other bacterial genera, like Lactobacilli, are folate consumers (12). Gut dysbiosis can therefore lead to hypo- or hypermethylation, depending on which genera predominate. Restoring a healthy gut microbiota can help bring methylation back in balance.

Reduce competition for methyl donors

Competition for methyl donors is another reason for impaired methylation. If one particular function of methylation is in overdrive, it may use up available methyl donors at the expense of other methylation functions. This is most often caused by environmental toxins, high histamine intake, high estrogens, acute or chronic stress, and chronic infection or immune challenges.

Reduce exposure to methylation inhibitors

Methylation inhibitors can also interfere with methylation-dependent functions in the body. Drugs that interfere with methylation include valproic acid, cholestyramine, oral contraceptives, PPIs, and antibiotics. Nitrous oxide, which some patients take at the dentist, is a known oxidizer of cobalamin (B12) (13). Studies have shown that metabolites produced by beneficial bacteria serve as critical cofactors and allosteric regulators of epigenetic processes (14, 15).

Rebalance methylation with methylation adaptogens

An “adaptogen” is a plant-based compound that promotes the body’s natural balance within a biochemical pathway, bringing the body back into homeostasis. The term “methylation adaptogen” was first coined by Dr. Michael Stone in Oregon and describes any compound that helps to restore methylation balance, both promoting appropriate methylation and inhibiting aberrant methylation.

Examples of methylation adaptogens include curcumin, betanin, anthocyanins, quercetin, rosmarinic acid, lycopene, and sulforaphane. These phytonutrients are found in abundance in a nutrient-dense diet, but additional supplementation may be helpful in some patients.

❗️Taking Folate and Feeling Badly? Methylation Requires Balance

mthfr.net/taking-folate-and...

💢💢Increased methylation can deplete dopamine, norepinephrine and 5-HT; increase acetylcholine; and cause hypokinesia and tremors. 💢💢

These effects are similar to changes seen in PD, and interestingly also, they are similar to some of the changes that are associated with the aging process. It is suggested, therefore, that increased methylation may be an inducing factor in parkinsonism.

❓Top 10 Foods Highest in Methionine

myfooddata.com/articles/hig...

[parkie13]

Thank you, thank you, Mary

[ConnieD]

Wow I really needed to read this thank you for all this information Kia!!😊

[Kia17]

You’re welcome

[Kia17]

Balancing Methylation

youtube.com/watch?v=dXaRti-...(Not working as expected?)

[Kia17]

Methylation is a biochemical process used throughout your body like a little light switches for turning on repairing DNA, producing energy, regulating hormones, detoxification, synthesizing neurotransmitters, and more. Undermethylation occurs when someone doesn’t have enough methyl groups to switch on certain processes. Most people methylate properly but if you fall on either end of the spectrum, you’re going to feel it.

google.co.uk/amp/s/www.jill...

[Kia17]

❗️ Please keep in mind that when you get a genetic test, you getting a list of possibilities and it is not definitive to whether or not you are undermethylating or overmethylating. That being said, it’s a good way to know which way your body might tend to behave.

[Kia17]

💢 The Incidence of Undermethylation (According to Walsh Research Institute’s research)(4):

98% of those on the Autism Spectrum clients at the Walsh Research Institute are undermethylated

95% of those with Antisocial Personality Disorder are undermethylated

90% of those with Schizoaffective Disorder are undermethylated

85% of those with Oppositional - Defiance are undermethylated

82% of those with Anorexia are undermethylated

38% of those with Depression are undermethylated 💢

[Kia17]

Causes of Undermethylation

undermethylation.com/causes/

[Kia17]

A Look at Overmethylation

blog.designsforhealth.com/n...

[Kia17]

💢💢 If you’re gluten-free or limit your intake of grains, you may be low in B6. Vitamin B6 is important to help you drive the transsulfuration cycle which means you may be low in your master antioxidant, glutathione.💢💢

suzycohen.com/articles/meth...

[LAJ12345]

Great stuff, thanks!

[LAJ12345]

This looks interesting too.

americanherbalistsguild.com...

[LAJ12345]

And this is a very good talk including the types of personality traits and what they might mean to whether you are over or under methylated or have another problem. I recommend listening to this if you can spare 1 1/2 hours as it explains many things very well like why different things work different people. Especially if you are taking folate.

m.youtube.com/watch?v=pHT3i...(Not working as expected?)

[Resano in reply to LAJ12345]

Methylation is a tricky thing, even more that both Undermethylation and Overmethylation conditions share common symptoms such as depression and anxiety. Before the onset of the disease, many PwP could well be undermethylated because of their perfectionism (a well known personality trait). So, when they engage, let us say in thiamine refeeding through, let us say again, TTFD, side effects (anxiety, etc.) may involve depletion of a methyl donor such as S-adenosyl methionine, to be ideally corrected through Overmethylation...