This was discussed here ( healthunlocked.com/parkinso...... ), but I thought it deserved to be highlighted.
NEWS ARTICLE 1:
pressreader.com/uk/the-sund...
It's a weird interface. First, click on the little green arrow beside the teaser text. Then click and drag the screen to scroll right to read the story.
PROMOTIONAL NEWS ARTICLE 2:
medium.com/parkinsons-uk/gd...
JOURNAL ARTICLE 1:
academic.oup.com/brain/arti...
JOURNAL ARTICLE 2:
could somebody translate did it work or not that's all I want to know
Documentary on TV in UK - BBC2 tonight (second part)
First part shown last week, should be available still on iplayer?
Some graphic scenes of operations last week so beware !
not sure because I didn't understand it
It failed in key areas...
newscientist.com/article/21...
I'm sure tonight's programme will still manage to put a positive twist on it! Anyway, you can encourage your own production of GDNF... READ Brant Cortright's book "Neurogenisis".
Most of the people involved in the trial were heartbroken they didn’t continue to get access to GDNF.
Was this because they already felt better? If so was this a placebo reaction? Was it because they had invested huge hope in this and weren't willing to throw in the towel? You could see on the programme how desperate they were. I think that upset me the most when watching the programme - what they were willing to go through with no promise of success and in the beginning, not even any promise of having the GDNF rather than a placebo.
Also... if putting GDNF into the brain had have worked, do we really think the overstretched NHS could afford to give us all brain surgery to put in the catheters and then have us back every month to pump in the GDNF? The whole thing to me suggests the idea that the more complicated, dangerous, and expensive a treatment is, the more likely it is to work. High dose thiamine has better results, is safe, is cheap... Why look elsewhere!
It's not really more invasive than stem cell transplantation - the main alternative therapy for dopamine neuron replacement. Nor more expensive. And its main failing was not that it didn't work, but that the placebo effect also worked. It's ongoing research, with potential benefits.
I am interested in pursuing HDT for me personally, in principal, but even the most casual review of posts on this forum reveals plenty of people who have tried it and received little or no benefit. As such it is not a one-stop perfect therapy for everyone- and that may be a reason to look elsewhere.
Why close doors? Why not look in as many places as possible to find a cure. And not just exclusively a silver bullet cure, but therapies which help slow the disease, or relieve its symptoms better.
Well said Pooh.
As to success or failure, failure maybe by scientific measurements and success to the participants. Which opinions do people think are more important. After all HDT maybe is working by placebo but it is working for many.
This method is not viable longterm for the NHS and it will not want to be providing this procedure but the trial is abeginning and there hopefully will be ongoing refinements and developments, that could be used.
My dad is in hospital this week for bowel cancer surgery. He was operated on Wednesday and had a bad bleed overnight so was in surgery again on Thursday and has been in ITU the rest of the time. My mother in law had the same surgery 2 years ago. I doubt very much the total hospital cost is less than the brain surgery. So why would the NHS not pay for this if it works?
Just watched the 2nd episode. Failure never looked so good. Maybe some people commenting should watch the program. Some f*****g awesome placebo effects
What a guy that Tom is
Yes, can somebody tell me a bit more >>> a belgian friend has posted several times that
I really have to look the second part......but I can not login or something like that
Is that the main conclusion like WinnieThePoo says : "some f*****g awesome placebo effects" ????
You might be interested in the Science of Parkinson's blog article on the topic:
scienceofparkinsons.com/201...
quote:
~~~~~~
The results of the study suggest that there was no difference in OFF
or ON performance at the 40 week timepoint between the GDNF and placebo
treated group. As you can see in the graph below, both group began
improving soon after treatment began, and they both continued to do so
across the 40 weeks of the study. A decrease in UPDRS score suggests an
improvement in the motor performance of the participants, and both the
red line (GDNF treatment) and the blue line (Placebo group) on the graph
have a downward tragectory.
scienceofpd.files.wordpress...
Source: Brain
Admittedly, the red line is lower than the blue line, but this never gets statistically significant.
~~~~~
What's interesting to me is that stroke can induce changes in astrocytes that put them in a sort of 'repair-mode'; it is possible the procedure itself induces similar changes. Or perhaps it is a more traditional placebo effect - the expectation of healing leads to physiological changes which promote healing.
~
For more on reactive astrocytes:
Thank you very much--------so I will continue by doing my exercises and also try to
follow what Mister Sigmund Freud once said : "before you diagnose yourself with depression or low self-esteem, first make sure you are not, in fact, surrounded by assholes"
Below is a link to a post by Jeeves19 which has YouTube links to both parts of the program. The links are in the comments.
Does it indicate failure of another clinical trial
Has Anybody Figured Out How to Get Farnesol?
Hopamine as Personalized Medicine for Persons with Parkinson’s Disease 
Hope bioscience is enrolling in 2 clinical trials 
Bilateral Pallidothalamic Tractotomy (PTT) Clinical Trials in the United States 
