The journey of Levodopa inside the intestine.

[Fed1000]

In his blog of 9 February "BAC for the future", Simon of Science of Parkinson's remembers that Levodopa is converted into Dopamine by an enzyme called Decarboxylase DOPA. He also says that outside the brain there is a lot of decarboxylase dopa in other organs of the body, so there is a risk that Levodopa will be converted into Dopamine before it reaches it, with a consequent reduction in benefits. It is the case of Tyrosine Decarboxylase which converts Levodopa in Dopamine despite the presence of Carbidopa wich is a decarboxylase inhibitor. Therefore I wonder if drinking a lot at the time of taking Levodopa may be some solution.

[Gioc]

For the series: "problems and solutions and related foundations" here is something that might interest you.

Thanks to Wriga.

researchgate.net/publicatio...

[Fed1000 in reply to Gioc]

Thanks GioCas.

[wriga in reply to Gioc]

Thanks Gio,

I had already read Simon's article on intestinal tyrosine decarboxylase. I'm now quite certain that there's a lot more to be done on enzyme inhibitors. I sent my article about CYP enzymes to Simon and he sent me back some useful ideas which helped me probe more deeply into this exciting subject. This article is now out of date for me. I'm now writing a new article that will explain, among other things, why the pharma companies will probably not develop CYP enzyme inhibitors for Parkinsons, not because they wouldn't work (they work for me !) but because of the risk of serious drug/drug interactions for patients with multiple pathologies. This would call for very personalised knowledge and supervision to avoid medical accidents, so too risky for big pharma. I will post it in a few days.

Gio, how are you doing ?

[Gioc in reply to wriga]

Wriga ,

I've been trying the CJ for a week with caution, but it will take a while to find my dose, I will also use thistle and licorice. It looks promising.

Thank you very much.

Please share with us , I am very interesting. 🙏

Gio

[wriga in reply to Gioc]

Hi again Gio,

I don't think thistle and licorice are needed. The most important enzyme is CYP3A4, especially in the gut lining (70% of all CYPs here is the 3A4 type and its the most potent ) This massively inactivates l-dopa. The effect is much greater than DDC or TDC. GJ deals with this progressively but it can take a few weeks. Next stage is CYP3A4 in the liver which can only be partially inhibited when the gut is cleared otherwise GJ can't get through to liver. Don't try to rush it.

[Gioc in reply to wriga]

Ah! Thank you very much. I re study everything now!

[Fed1000 in reply to wriga]

Thanks Wriga.