It appears that an abundance of bad probiotics in the gut can help alpha-synuclein proliferate. The key then would be to eat a lot of dietary fibre to feed the good probiotics, take probiotic capsules, and also eat fermented foods. A gut that is healthy restricts the proliferation of bad bacteria.
sciencedirect.com/science/a...
I just wish I studied nutrition, then I might be better able to understand some of these words in scientific articles.
Very interesting Getz. Have you had any success with the helmet??
Hi Munchy, I think my problems are improving. Very little tremor at all now and my feet are only just tingling. Don't know whether it's the helmet or whether its the combination of everything. Have been reading about HGH (human growth hormone) and how necessary it is for cellular regeneration, as well as BDNF and Butyrate and the article was an outcome of following a few links. The way I see it is if we can get rid of the a-synuclein and grow new neurons we might have half a chance of getting rid of PD. The gut then has become so important as that's where the a-synuclein starts and travels up the vagus nerve to the brain where it does its tangling. It seems that an abundance of good bacteria gets rid of a-synuclein in the gut and there is one strain that specifically attacks it. Unfortunately I didn't write it down and am now searching for it. I'm hoping that HGH and BDNF will help in neurogenesis and maybe there's something that can clean up the tangles left in the brain which interfere with the messages.
Hope all is well with you.
What’s hgn? Do you use the nose thing too or just the helmet? Had the helmet helped yr thinking? Thanks Getz !
HGH is human growth hormone which stops growing early in life. Its pretty sensible to keep up supplies as we age so we can keep our bodies in good shape.
The intranasal light has been put on the backburner a bit as I was doing too many things including intra-nasal frankincense (which gave me a runny nose so I stopped).
Bone broth or collagen are also good for the gut.
No argument there at all. Great foods to feed just about every positive thing our body needs, The above article actually specifies probiotics, prebiotics, and synbiotics to reduce alpha-synuclein. Its just so damned hard to read though so I'm currently trying to rewrite it in ordinary language and having a heap of trouble.
Thank you, Getz. This is useful article underpinned by a great deal of research.
Thanks for posting. So what is a good source of that magical good bacteria that are gut needs to clean up those misfolding proteins?
5.2. Probiotics
Probiotics are specific microorganisms that when administered in adequate amounts can exert a health benefit on the host by restoring microbiota and maintaining immune homeostasis The most common probiotic bacteria currently used are representatives of Lactobacilli, Enterococci, Bifidobacteria, and yeasts. Various studies have reported the beneficial effects of probiotics by enhancing intestinal epithelial integrity, protecting from barrier disruption, stimulating a healthy homeostasis of the mucosal immune system and suppressing pathogenic bacterial growth. Moreover, different strains of probiotic bacteria have been shown to be effective in stimulating intestinal motility and reducing GI dysfunction. For example, in elderly orthopedic patients, probiotics showed to have positive effects on bowel movements by lowering the incidence of diarrhea and constipation severity (Zaharoni et al., 2011). In a double blind placebo controlled trial, Lactobacillus reuteri supplementation improved bowel movement frequency in adults with chronic functional constipations, but did not show to have an effect on stool consistency (Ojetti et al., 2014). Furthermore, studies have shown that it is possible to modulate brain function by improving anxiety and depression using probiotics. In a mouse model of autism spectrum disorder (ASD), Hsiao and colleagues showed that the administration of Bacteroides fragilis reversed the abnormalities in gut permeability and ASD related behaviors (Hsiao et al., 2013). Ingestion of selected probiotics also exhibited beneficial effects on brain function in humans. The administration of Lactobacillus casei strain Shirota in chronic fatigue syndrome patients significantly decreased anxiety symptoms (Rao et al., 2009). Studies regarding the use of probiotics for the treatment of PD are very limited. One study showed that PD patients suffering from chronic constipation receiving fermented milk containing Lactobacillus casei Shirota for five weeks improved stool consistency and reduced bloating and abdominal pain (Cassani et al., 2011).
Probiotics might be a powerful tool in order to alter PD-associated microbiota composition and improve GI function and therefore reduce gut leakiness, bacterial translocation and the associated neuro-inflammation in the ENS. Improving GI function by supplementation with probiotics might not solely lead to a better functionality and/or protection of the intestine, but might also improve levodopaabsorption and reduce behavioral and cognitive deficits such as anxiety, depression and memory problems (Liang et al., 2015, Maes et al., 2008), which are common in PD patients.
Sections 5.2, 5.3 & 5.4 are about prebiotics, probiotics and synbiotics and although it is clear that the gut is where alpha-synuclein starts this article talks about the good one. I am still searching for my article that listed a specific probiotic that attacked a-synuclein. In the meantime there's some great info on boosting HGH and BDNF nutritionally and what to eat for a healthy gut. Most articles say a healthy microbiome will minimize bad flora.
While looking for an article I read about Lactobacillus Plantarum cleaning up alpha synuclein I came across another article which lists a whole host of probiotics which have a great effect on cleaning up the cause of most health problems.
realnatural.org/parkinsons-...
Hi Getz. Is the probiotic clostridium butyrate the one that is effective in improving gut biome and clearing up the alpha synuclein?
Or do we just take any probiotic that is 100 billion ?
Millbrook, I have no idea. It is however becoming increasingly clear that good gut flora are a key to good health. I certainly spread Ghee over my cooked dinner veges as I read somewhere that it builds up butyrate which does something in the brain. I just wish I'd studied science, particularly biology, as I may then understand some of these articles.
Getting Back To The Gut Of The Matter And Some Real Hope!
Quite an interesting article. Thoughts?
Probiotics? Are they helpful? BioKult? Dr. Mischley says no probiotics but not why? 
The Gut-Brain Connection: How it Works and The Role of Nutrition; Explained in layman's language as per Healthline
Interesting article in support of MSM methylsulfonylmethane
