My Mom has PD and has been taking C-L with relative stability, but would go through "off-times" routinely 2 hours after taking her meds. In order to prevent this, her doctor started her on Sinemet CR, hoping it would provide a smoother day, with less severe "off times". Her doctor eased her into the Sinamet CR, but she's now been taking her 25-100 dose 4x/day for almost two weeks. Ever since she switched fully to the Sinamet CR she has had no relief from tremors and is basically in a constant "off". Her doctor wants her to stick it out to see if things change. Has anyone had experience like this? Where the medication did not seem to work at all? Did it ever begin working better? I'm beginning to think she needs to switch back to C-L and find another way to deal with her 'off-times'.