Use of ibuprofen and risk of Parkinso... - Parkinson's Movement

Parkinson's Movement
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Use of ibuprofen and risk of Parkinson disease

Use of nonsteroidal anti-inflammatory drugs (NSAID) in general, and possibly ibuprofen in particular, has been shown to be related to lower PD risk in previous epidemiologic studies.

ncbi.nlm.nih.gov/m/pubmed/2...

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It may possibly also have a treatment effect with proper delivery :

ncbi.nlm.nih.gov/pmc/articl...

Art

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I’ve noticed when I take ketoprofen for my back pain I feel noticeably better for hours including my tremor gets a bit reduced.. I take it since almost a year, not regularly only when I need it. I am sure of what I am saying. I didn’t want to stir up the forum about this, but fact…

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you are right. I too have the same experience

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Be careful with long-term use of ibuprofen. Have a read of this comment by Simon in an SoPD blog post from earlier this year.

scienceofparkinsons.com/201...

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Topical use of ibuprofen can virtually eliminate the potential for gastric issues and the mouse study used a nasal application which would likely also greatly reduce or eliminate that potential.

Art

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Topical use? Now THAT sounds like an interesting PD experiment!

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I wrote a little about topical ibuprofen here :

healthunlocked.com/parkinso...

Art

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But the thread you linked to is about pain relief, and does not mention PD?

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The use for PD is as yet unproven and the mouse study used a nasal application in a microgel formulation. Just a mouse study, not a human study. I imagine that topical application to the spinal area might be helpful, but that has no studies to confirm.

Art

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Careful about effects of ibuprofen on kidneys.

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