Use of ibuprofen and risk of Parkinson disease

[Farooqji]

Use of nonsteroidal anti-inflammatory drugs (NSAID) in general, and possibly ibuprofen in particular, has been shown to be related to lower PD risk in previous epidemiologic studies.

ncbi.nlm.nih.gov/m/pubmed/2...

[Hidden]

It may possibly also have a treatment effect with proper delivery :

ncbi.nlm.nih.gov/pmc/articl...

Art

[dadcor]

I’ve noticed when I take ketoprofen for my back pain I feel noticeably better for hours including my tremor gets a bit reduced.. I take it since almost a year, not regularly only when I need it. I am sure of what I am saying. I didn’t want to stir up the forum about this, but fact…

[Farooqji in reply to dadcor]

you are right. I too have the same experience

[jeffreyn]

Be careful with long-term use of ibuprofen. Have a read of this comment by Simon in an SoPD blog post from earlier this year.

scienceofparkinsons.com/201...

[Hidden in reply to jeffreyn]

Topical use of ibuprofen can virtually eliminate the potential for gastric issues and the mouse study used a nasal application which would likely also greatly reduce or eliminate that potential.

Art

[jeffreyn in reply to Hidden]

Topical use? Now THAT sounds like an interesting PD experiment!

[Hidden in reply to jeffreyn]

I wrote a little about topical ibuprofen here :

healthunlocked.com/parkinso...

Art

[jeffreyn in reply to Hidden]

But the thread you linked to is about pain relief, and does not mention PD?

[Hidden in reply to jeffreyn]

The use for PD is as yet unproven and the mouse study used a nasal application in a microgel formulation. Just a mouse study, not a human study. I imagine that topical application to the spinal area might be helpful, but that has no studies to confirm.

Art

[PJSammy]

Careful about effects of ibuprofen on kidneys.