Most cited research paper on PD

[Farooqji]

it's about effectiveness of Minocycline in neural cells protection. This paper dates back to 2002. I don't know why the research didn't progress further on this topic

google.com.pk/url?sa=t&sour...

[park_bear]

It has been studied and failed:

ncbi.nlm.nih.gov/pmc/articl...

Published online 2015 Nov 11. doi: [10.1016/j.coph.2015.10.006]

Immunomodulation as a neuroprotective and therapeutic strategy for Parkinson’s disease

However, in the clinical setting, neuroimaging analysis of PD patients following minocycline treatment suggest that microglial activation is perturbed, but motor assessments failed to show any clinical benefit [23–25]. In conclusion, anti-inflammatory agents, while having been extensively studied, have failed to provide improved clinical outcomes.

Mov Disord. 2010 Jan 15;25(1):97-107. doi: 10.1002/mds.22732.

Minocycline 1-year therapy in multiple-system-atrophy: effect on clinical symptoms

Abstract

The aim of the study was to investigate the efficacy of the antibiotic minocycline as a drug treatment in patients with Multiple-System-Atrophy Parkinson-type (MSA-P). Sixty-three patients were randomized to minocycline 200 mg/d (n = 32) or a matching placebo (n = 31). .... At 24 weeks and 48 weeks of follow-up, there was a significant deterioration in motor scores in both groups, but neither the change in UMSARSII nor in UPDRSIII differed significantly between treatment groups, i.e. "progression rate" was considered to be similar in both treatment arms. HrQoL did not differ among the two treatment arms. In a small subgroup of patients (n = 8; minocycline = 3, placebo = 5)[(11)C](R)-PK11195-PET was performed. The three patients in the minocycline group had an attenuated mean increase in microglial activation as compared to the placebo group (P = 0.07) and in two of them individually showed decreased [11C](R)-PK11195 binding actually decreased. These preliminary PET-data suggest that minocycline may interfere with microglial activation. The relevance of this observation requires further investigation. This prospective, 48 week, randomized, double-blind, multinational study failed to show a clinical effect of minocycline on symptom severity as assessed by clinical motor function.

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ncbi.nlm.nih.gov/pmc/articl...

Clin Neuropharmacol. 2008 May-Jun; 31(3): 141–150

A Pilot Clinical Trial of Creatine and Minocycline in Early Parkinson Disease: 18-Month

Results

By 18 months, symptomatic treatment of PD symptoms was required in 61% of creatine, 62% of minocycline, and 60% of placebo-treated subjects. Study treatment was prematurely discontinued in 9%, 23%, and 6% of subjects in the creatine, minocycline, and placebo arms, respectively. Creatine and minocycline did not seem to adversely influence the response to symptomatic therapy nor increase adverse events.

[football10]

taking levodopa along with thiamine according to DR C is the most effective way to stop tremors. has anyone been taking ONLY levodopa and thiaminefor at least two years with no side effec ts from levodopa? did your tremor diminish? what was your results?