Log in
Parkinson's Movement
15,001 members13,488 posts

Enzymes to dissolve the alpha-synuclein protein build up in the brain.

I have just read about this alpha-synuclein protein as being a contributor to PD and am wondering if anyone knows or has come across any research on how to dissolve it using natural enzymes.

The reason I ask is that cancer cells protect themselves from our immune system by coating themselves with fibrin to give the same charge as our natural killer cells. Fibrin is a protein and has shown to be broken down by proteolytic enzymes such as bromelain (pineapple) and papain (papaya) and serapeptase (silk worm) which then exposes the cancer cells to the NKC which then attack them.

I was wondering if anyone had heard of any enzymes which would do the same to this alpha-synuclein protein.

33 Replies
oldestnewest

I think mannitol does this?

3 likes
Reply

Thanks Munchy. Looked it up on Wikipedia and has some awful side effects. Was hoping for something natural. Pineapple and papaya are delicious together, either cut up or blended.

Reply

I haven’t heard of harmful side effects associated with mannitol. My understanding is it’s a harmless sugar Which may help.

1 like
Reply

Enzyme tend to be big molecules. There is a question as to whether they are able to make through the gut intact, not to mention the blood-brain barrier.

2 likes
Reply

You may want to look further into this.

Targeting PDE1 for PD | The Science of Parkinson's

Oct 23, 2018 · Only PDE1 inhibition (Vinpocetine) reduced alpha synuclein toxicity.

ncbi.nlm.nih.gov/pmc/articl...

Vinpocetine is a supplement founding your local health food store or on line. I’ve been taking it since November 2nd with positive results.

1 like
Reply

Great article, I think!!!! Just a pity I couldn't understand the scientific language but I inferred that the general gist of it was positive for something that could minimize the effect of alpha-synuclein. Only problem is I don't know what this is, where to get it, and if it is present in a natural food.

Reply

Followed up on your vinpocetine lead which was mentioned in the ncbi link, and found it is extracted from the lessor periwinkle plant which is a herb. The following link puts it in a questionable category. webmd.com/vitamins/ai/ingre... Really interesting reading though and worth exploring further. Old name was 'violet of the sorcerers' so has been used in Europe for a very long time. Just need to find out how it was used.

Really interesting. Thank you.

Reply

This article is about periwinkle. Vinpocetine is not the same. Although vinpocetine is derived from periwinkle they are not the same and are not comparable. Vinpocetine has not shown the same hazards as periwinkle itself and goes through significant man made synthesis after the initial extraction of Vincamine from the plant. Nerve, kidney and liver damage are not seen in vinpocetine at the doses used in human studies. Periwinkle is also used to make anticancer agents like vinblastine and vincristine to name just two. Periwinkle has multiple active components and each is different than the plant as a whole.

Art

5 likes
Reply

I think the Vinpocetine is a synthetic derivative which doesn’t sound quite as dangerous webmd.com/vitamins/ai/ingre...

2 likes
Reply

I read that blueberries help and I've been eating them since.

3 likes
Reply

It's more complex than that. We all have alpha synuclein in our brains. Parkinson's is (probably, no one is even sure) caused when the normal, single strands of alpha synuclein twist with other strands to form damaging clumps. And no one really knows why that happens either. Or how to stop it.

Much of the stuff that helps is simply to "shore up" existing nerve cells--so they're better able to take the onslaught. That would be like blueberries. As far as I know, they do nothing specific for alpha synuclein clumps. They are an anti oxidant (like many other colorful fruits and veggies) and good for cells in general.

Go to the Science of Parkinson's website. He does a pretty good job of explaining all this stuff, and also all the breakthroughs in treatments.

1 like
Reply

Thanks amykp. Links like this 'Science of Parkinson's' are just what the doctor ordered. I'm still trying to get my head around it in the hope of finding a nutritional solution.

Reply

I eat a ketogenic diet, which I think helps me (it's generally neuroprotective, meaning, it helps neurons stay healthy. It's not a cure, just a slow-down--I believe.) Anyway, I take no dopamine replacement...yet, and my symptoms are still very mild and one-sided after four years. But the diet takes commitment a lot of folks simply aren't willing to make!

3 likes
Reply

amukp,

I think the same.

Reply

I agree. I’ve been on the Keto diet since shortly after I was diagnosed in April...I feel like it has helped to slow the progression but I also take a lot of supplements. I also take Selegeline.

Reply

Getz, if you search Vinpocetine on this site “HealthUnlocked” you’ll find some previous discussions.

2 likes
Reply
1 like
Reply

Thanks GioCas. Its obvious that I have a lot to learn about this site and have now found The Science of Parkinson's as well. Much appreciated.

1 like
Reply

I think we are looking at the Alpha-Synuclein removal in a way that we want to remove stains from our clothes in washing machine.The alpha-synuclein protein becomes a part of our Dopamine producing neurons in substantia nigra and make them something like being calcified.

All the experiments about breaking a-syncuclein carried out on worms or similar which have very simple neurological system compared to the human’s complex system and some of those substances that we hear everyday can only break alpha-synuclein in Lab.

I have been personally taking Mannitol blindly for a year but I think Mannitol is likely to reduce the intera-cranial pressure than breaking the A/S protein down.

In the ICU Mannitol infusion is for people with head trauma to reduce the Intera-Cranial pressure and inflammation.

Even any of these substances make through the BBB , then what happens,?? do they break the A/S and restore the cells? I don’t think so.I cannot digest it. Please somebody enlighten me if I am wrong.

1 like
Reply

Serrapeptase

2 likes
Reply

Thanks Kimie13. Only problem is I've been taking serapeptase to ensure prostate cancer doesn't return but only taking 1 capsule a day. Looks like I'll have to up the dose. Would just love it if there was some specific research to back it up.

Reply

This was so interesting. A little technical at times but very informative

1 like
Reply

this video was very interesting. I had not heard about Chiro treatment for PD. Who is the presenter? Thanks - John G (reedboat2)

Reply

OK I got it, Dr John Bergman - thanks again for posting.

John G

Reply

Took me a while but finally watched it all the way through. Thanks Kimie13. Really good video with lots of practical suggestions to add to my routine.

Reply

i use fresh pineapple and fresh papaya along with my supplement routine that includes mannitol and 500 mg of thiamine and tumeric/ginger/green tea made fresh daily. I hate to say it for fear that the gods will hear me and interfere, but i feel wonderful. I also hit the gym 4 days a week and have rediscovered coffee for energy. good luck!!!

I recently started 30 mg of Vinpocetine daily. that has improved foot neuropathy greatly.

1 like
Reply

nineveh,

These 18 repeat posts are a sure fire way to get people to not have confidence in what you are trying to sell.

The fact that you just joined the forum today doesn't help either!

Reply

Many people will consider this spam because you are only posting one thing that is not germane to the topics you are responding to and 18 repeat posts that are exactly the same makes it seem even more like spam!

2 likes
Reply

It's not exactly "natural", although it is supposed to be derived from a shark protein:

enterininc.com/

I'm participating in a trial for Kenterin (or more correctly ENT-01). I've been taking this daily for about 3 weeks so far.

1 like
Reply

This sounds like a great treatment but does it clear the a-synuclein from the neurons in the brain? The link talks about it clearing it out of the gut and the nerve. Can I (Australia) get on the trial? Please keep us informed. Good Luck.

Reply

The short answer is they don't know yet if it will have any effect on the brain. This is a relatively short (about 2 months) trial of 75 PwP, mostly to find out what dose is tolerated and to test its effect on constipation. If all goes well, a much larger and longer trial should start late this year to test much more. Obviously, this sort of drug is very different from one that masks symptoms in that it's trying to flush out the a-S and that would probably take months at least. I dont know if the trial has enough participants. I'll check the list to see if Australia's on it.

1 like
Reply

Many thanks. If it works it would be something to take as soon as there was any indication of PD. That way a-s would not be able to build up any further in the brain and some of the devices such as the NIR helmet, or the 40hz light and sound devices may clear what has made it into the brain.

Reply

There are no sites listed in Australia. Maybe for the larger study. Here's the link to this trial: clinicaltrials.gov/ct2/show...

1 like
Reply