Many PWP take several supplements and I'm one of them, but as more research is done or I come across research I haven't seen before, I find out that a supplement may have a negative effect on PD or health in general. I'm starting this thread to share and discover more about these sometimes tricky things we call 'supplements'.
I'll start with one that many PWP take, and I used to take: Carnitine. Carnitine is used by our bodies in many helpful ways, so why not take more of it? We produce Carnitine, so there's no known requirement to take in more. But what's the problem if we do?
Briefly, it's now well established that we all have bacteria in our guts that break down whatever we ingest. Some of these bacteria convert Carnitine they find in our guts into TMA, trimethylamine. TMA is converted in our livers to an extremely inflammatory molecule: TMAO, trimethylamine-n-oxide, which then circulates throughout our bloodstream. This doesn't happen in the same way to Carnitine that we produce ourselves because that never gets into our guts where these bacteria live.
Carnitine is also in red meat, so if you cut down on red meat, you're also cutting down on your body's TMAO load and the system-wide inflammation it causes. It's interesting that long-term vegans don't have the bacteria that breaks Carnitine down into TMA, but if they begin taking Carnitine supplements, it grows in their guts too, and then they have the same problem. Vegan or not, Carnitine is not a healthy supplement to take, at least orally