I am currently on C/L 25/100 ER 3 times day but i have been having more off times lately so my movement specialist wants me to add one 2mg requip with my first dose in the morning.Anyone using this and how does it work for you? thanks everyone!
Anyone using Requip for Parkinsons? - Parkinson's Movement
Are you on CR or ER (Rytary)?
To put the proposed change into perspective, the levodopa equivalent dose of:
25/100mg C/L CR is 70mg (scaling factor is 0.7), TMAX = 120 minutes
2mg ropinirole (Requip) is 40mg (scaling factor is 20), TMAX = 90 minutes
Whether the proposal is a good idea depends on what you're trying to achieve. If it's to give you a boost in the morning a small dose of C/L immediate release (TMAX = 60 minutes) may be a better option. If it's to get a firm foundation in order to get less variable relief, ropinirole extended relief may be a better option than the IR version.
Requip is a dopamine agonist. Before you get started down this road be aware that dopamine agonists cause impulse control disorders in up to 50% of patients - compulsive gambling, shopping, eating or sexuality. Dopamine agonists also cause orthostatic hypotension in about one third of patients – orthostatic hypotension means loss of blood pressure upon standing with possible fainting and uncontrolled falls.
You are by no means maxed out on your C/L. You could try adding an additional dose, or starting an MAO-B inhibitor such as Azilect.
Azilect is a different class of drug, an MAO-B inhibitor. That means is that it inhibits the enzyme that breaks down dopamine. It does not cause the adverse effects of dopamine agonists. It works synergistically with C/L. If it does not work for you, you can stop taking it without adverse consequences.
Medical journals are full of propaganda planted by big Pharmas. Some doctors have bought into the system, or least do not know any better - they have been propagandized ever since med school. See my writing here for further discussion of this issue:
When Good Doctors Prescribe Bad Medicine
I have been on three drugs since first diagnosed by a movement disorder specialist: carbidopa/levodopa, roprinerole and Rasagelene (Azilect). I am on my third movement disorders doc (they change jobs) and they all agree on the three-drug combo. I have questioned them. Over time dose of first two has been raised to reduce off times. i have not experienced any serious side effects from roprinerole.
Hi RobynS, I personally had a bad experience with Dopermine agonist meds. What I would say to you is if you up the dosage please ask your family or friends to to keep a careful watch over you They need to tell you if they see any changes in personality, mood ect, DA's can cause excessive behaviours in some people. I experienced it first hand and my excessive behavior caused us to go bankrupt. Take care and good luck.
Gypsy i am sorry to hear of this i dont know why these Dr's want to experiment with us like lab rats! it angers me.I have been taking it for 2 days and feel very sleepy almost like a zombie! i work full time and cant work like this.I have heard more bad things than good so i may tell her i dont want to take it.
Hi RobynS I too was like a zombie while I took it, I was working full time on the Isle of Man as a social worker. I can recall almost driving off a cliff edge whilst on my way home one night. I had to keep apologizing to clients because I couldn't keep my eyes open while I interviewed them. Hope you can sort it, did your doctor warn you of the possibility of having some very complex side effects?
I have been on agonists for 10 years, and they have worked for me. You of course will hear the negatives more than the positives, people with negative experiences are often more vocal, but agonists are not all bad though i dont dismiss the experiences like gypsy had. They are very real too.
Requip made me very sleepy at first but in time my body adjusted. If taking long acting you can take it at night. Im on pramipexole now. L dopa too can also cause compulsive behaviour but it is rare.
I dont think doctors are experimenting on us, agonists have been used for some time but they should warn you particularly of compulsive behaviour. Also you should begin on a starter pack slowly increasing to 2 mg.
I like having the mix of agonist, l dopa and COMT inhibitor that I take, it gives me 5 hours on time between doses.
Its a hard decision to make and there are no right or wrongs.