Phase 3 Isradipine Results Coming Soon

[jimcaster]

The last person being studied in Phase 3 Israpidine study will be done this November. Results will be out 3 to 6 months later and it may be the first readily available drug shown to delay progression in PD.

parkinsonsdisease.net/resea...

[jimcaster]

More israpidine info: michaeljfox.org/foundation/...

[stepan13]

I am taking isradipine 5mg 2times a day for the last 5 years since I had been diagnosed. Still alive. Still have PD.

[jimcaster in reply to stepan13]

Since you have been taking it for five years, have you noticed a benefit -- such as slower disease progression than peer, etc.? Obviously, there's no way to know if your condition would be worse if you were not taking it, but I assume you must believe there is some benefit. I sure hope so. 😊

[WinnieThePoo]

I think there are signs this may be the first real disease modifier to make it to licencing. I hope that doesn't jinx it with "commentators curse". Since I have BP that is at best 140/90 and a French GP, who knows I want Isradipine for PD, prepared to prescribe it with a straight face for my hypertension, I have been exhibiting admirable restraint and calm in not popping this pill.

First, there has been a lot of press for lab tests with mice earlier this year suggesting an explanation of the method by which this drug slows PD. Second, this is a full blown large scale 3 year trial, and it has made it to the finish line. If results were evidently poor I suspect it would have blown up and finished early.

Exanatide is the other very promising drug, so its frustrating that its phase 3 has yet to get off the ground.

[bassofspades]

My 2 cents. I took isradipine for a year. No loss and no gain from it. But thiamine halts progression, resolves symptoms and is safe, so why not just use that? Isradipine is a blood pressure medication so risk of side effects is higher than b1.

[jimcaster in reply to bassofspades]

Bass, when you say "no loss and no gain" do you mean your symptoms stayed the same for a year? If so, that sounds great. I sure hope you are right regarding thiamine. I am now at the six month mark with thiamine and truly feel better than when I was diagnosed, but the lawyer in me keeps anticipating and/or preparing for the worst case scenario. Even though I keep telling myself to live for today, I keep worrying about tomorrow and wondering if this thiamine stuff is too good to be true. Although I'm growing increasingly frustrated with the established medical community, I just wish someone within the established research/medical community would validate or support Dr. Costantini's efforts...

[bassofspades in reply to jimcaster]

Just to clarify, no loss no gain means i didn't get worse or better. On thiamine, however, i did get better and i trust what Dr Costantini said about never getting worse. So therefore i see no point to isradipine. Thiamine is better in every way. At least that's my 2 cents. ...unless you are already using isradipine for your blood pressure. But my dr said its not commonly used for BP anymore. Used to be called Dynacirc.

[jimcaster in reply to bassofspades]

I sure hope you are right and I have nothing in my personal experience with thiamine to doubt you. When did you start on thiamine and what is your current dose? I started around May 20 and have settled in at 1.5 grams per day.

[bassofspades in reply to jimcaster]

Started in feb 2018. Currently on 2.5 g per day. Started with 4, then 3, then 2.5g. It's been great for me.

[bassofspades in reply to jimcaster]

Have faith, dr. Costantini knows what he is doing.

[Highway17]

Not good news. Results just released at AAN Conference were negative aan.com/PressRoom/Home/Pres...

[jimcaster in reply to Highway17]

I wish there was an icon other than a thumbs up. This is a thumbs down for sure. Dang.