Hi, something about IL-17 !! (and also Stemmcell)

[JANVAN]

Here an interesting link !!

scienceofparkinsons.com/201...

Try to "convince" your neurologist and naturopath >>>> because it will last two

years for results out of the trials.......

(an more extensive post I've send to Iqbaliqbal)

Thanks everybody !!!

[Hidden]

JANVAN,

I am a little familiar with IL-17 because it is a major player in psoriasis and other inflammatory conditions. The biologics that seek to down regulate this inflammatory mediator in order to help control runaway inflammation come with potential for significant side effects.

fda.gov/downloads/drugs/dru...

There are natural IL-17 inhibitors that come with the potential for other health benefits such as probiotics of the right type, egcg/green tea, vitamin d, pine bark extract and curcumin to name a few. I used some of these to gain complete control of my very severe psoriasis.

Here is a brief PubMed abstract that illustrates how probiotics can do this in humans.

Art

:::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::

Crit Care Med. 2018 Jun 27. doi: 10.1097/CCM.0000000000003279. [Epub ahead of print]

Evaluation of Effect of Probiotics on Cytokine Levels in Critically Ill Children With Severe Sepsis: A Double-Blind, Placebo-Controlled Trial.

Angurana SK1, Bansal A1, Singhi S1,2, Aggarwal R3, Jayashree M1, Salaria M3, Mangat NK3.

Author information

Abstract

OBJECTIVES:

To evaluate the effect of probiotics on cytokines in children with severe sepsis.

DESIGN:

Randomized, double-blind, placebo-controlled trial.

SETTING:

ICU of a tertiary care teaching hospital in North India.

PATIENTS:

Children 3 months to 12 years old with severe sepsis.

INTERVENTIONS:

Enrolled children were randomized to probiotic (n = 50) and placebo (n = 50) groups. Probiotic group received VSL#3 (VSL Pharmaceuticals, Towson, MD) (Lactobacillus paracasei, L. plantarum, L. acidophilus, L. delbrueckii, Bifidobacterium longum, B. breve, B. infantis, Streptococcus salivarius; maltose; and silicon dioxide), and placebo group received maltose and silicon dioxide. Dose was 1 sachet twice daily for 7 days. Blood was collected on days 1 and 7 for estimation of interleukin-6, interleukin-12p70, interleukin-17, tumor necrosis factor-α, interleukin-10, and transforming growth factor -β1. "Primary outcome": Change in cytokine levels in probiotic and placebo groups from day 1 to 7. "Secondary outcomes": Sequential Organ Failure Assessment score, healthcare-associated infections, ICU stay, and mortality.

MEASUREMENTS AND MAIN RESULTS:

On day 7, probiotic group had significantly lower levels of proinflammatory cytokines (interleukin-6 [80 vs 186 pg/mL, p = 0.001]; interleukin-12p70 [44 vs 79 pg/mL, p = 0.001]; interleukin-17 [217 vs 293 pg/mL, p = 0.01]; and tumor necrosis factor-α [192 vs 348 pg/mL, p = 0.01]) and higher levels of antiinflammatory cytokines (interleukin-10 [320 vs 240 pg/mL, p = 0.02] and TGF-β1 [311 vs 221 ng/mL, p = 0.01]) than placebo group. From day 1 to 7, probiotic group showed significant decrease in proinflammatory cytokines (interleukin-6 [196-80 pg/mL, p = 0.001]; interleukin-12p70 [71-44 pg/mL, p = 0.01]; interleukin-17 [258-217 pg/mL, p = 0.01]; and tumor necrosis factor-α [347-192 pg/mL, p = 0.001]) and increase in antiinflammatory cytokines (interleukin-10 [198-320 pg/mL, p = 0.001] and TGF-β1 [216-311 ng/mL, p = 0.001]) as compared to placebo group. Sequential Organ Failure Assessment score on day 7 was significantly less in probiotic group (1 vs 3). There was a nonsignificant trend toward lower incidence of HCAIs (14% vs 20%) and duration of ICU stay (6.5 vs 9 d) in probiotic group. Mortality was similar in two groups.

CONCLUSIONS:

Probiotics supplementation for 7 days resulted in significant decrease in proinflammatory and increase in antiinflammatory cytokines in children with severe sepsis.

PMID: 29957709 DOI: 10.1097/CCM.0000000000003279

Share on FacebookShare on TwitterShare on Google+

[parkie13 in reply to Hidden]

Art, I'm sure it's been covered, but what kind of probiotics were you using? Thanks Mary

[Hidden in reply to parkie13]

parkie13,

Yes, it has been discussed previously in this thread which expands even further on the value of probiotics in relation to PWPs.

healthunlocked.com/parkinso...

I use a product called, Epic Pro 25-Strain Probiotic, but it sounds like Gio and possibly Kia17 have gotten benefit from two others. Their experience is also discussed in the above link. I also added to that link today with some interesting information from a couple of newer studies related to what JANVAN is discussing in the post above.

Art

[Juliegrace in reply to Hidden]

Someone else posted this article a couple of days ago (it's easier for me to link to the article than the HU post on my iPad). You and Mary might find it interesting.

sciencedaily.com/releases/2...

[parkie13 in reply to Hidden]

I took something for a month it is called Rege 'Active detox and Liver Health, it has lactobacillus fermentum me - 3, it is supposed to produce glutathione. What I noticed is that my stomach is feeling way better. About the glutathione I am not sure, how do you tell?

Robert Rogers mentioned it was a very good product and it was hard to make it, right now it's pretty much unavailable. It was pretty expensive too. Thank you both Mary

[davissw in reply to parkie13]

I have been taking the reg'Active for about 6 months. I have less bloating and my belly seems to have shrunk. It is mostly unavailable because it has been endorsed by so many doctors. I talked to Gayle at Ohira Probiotics yesterday. She said one of their other probiotics, the one for cardio, had the same ingredient that produced the glutathione was available. It did not get the same publicity.

[parkie13 in reply to davissw]

They have about three different kinds with the same probiotic and different supporting ingredients for different afflictions. Right now the cheapest that you can find is $50 on Amazon I believe.

[parkie13 in reply to davissw]

Hi, are they in the process of making some more? Right now it's a very very hot and I didn't want to order it till it cools down because I'm not sure if they survive heat conditions.

[Gioc]

"Probiotics should be treated as a drug, not as a food supplement," Rao says, noting that many individuals self-prescribe the live bacteria, which are considered good for digestion and overall health.

mah! What does it mean ? what will take a recipe? When I hear a researcher make these considerations, I am puzzled as there are millions of people who use probiotics also made at home.

[Hidden in reply to Gioc]

I agree with you, Gio, It was a bad study, no matter how you slice it!

Art

[Juliegrace]

ncbi.nlm.nih.gov/pubmed/299...

FWIW

[Gioc in reply to Juliegrace]

Very interesting, certainly reading the study is quite another thing. Since I was working in contact with refrigerated and conditioned environments, with PD and gastroesophageal reflux and PPI use, I occasionally suffered from vertigo and slow bowel. The point was resolved with a special probiotic taken one-off, xylitol instead of other sweeteners to favor the prevotellaceous, few carbohydrates, and important cold basmati rice to make resistant starch. This put an end to vertigo, greatly increasing intestinal motility.Gio

[Hidden in reply to Juliegrace]

Yes, this is the full study I read.

From this you can see that they are trying to attribute the brain fogginess, gas and bloating to either probiotics, SIBO or lactic acidosis! All of the listed symptoms are symptoms of SIBO and possibly lactic acidosis, but probiotics do not cause SIBO or these symptoms! I have seen no other studies to support their suggestion. They say they discontinued probiotics and replaced them with antibiotics and then drew the conclusion that probiotics could be a potential cause of the SIBO because the patients then got better. One has nothing to do with the other. Antibiotics are the standard of care for SIBO and the patients would have improved if the probiotics were still being taken or not. This study is poorly designed and draws the unsupported suggestion that removing the probiotics "may have" caused the symptoms to diminish. In order to test that theory, they should have removed the probiotics from half of the SIBO patients and seen if the patients improved with the withdrawal of the probiotics, but instead they just gave the antibiotics and withdrew the probiotics at the same time. From that you can not suggest that probiotics was the cause of anything. The following studies suggest that probiotics are useful in helping to treat SIBO symptoms.

Here is a study that shows that probiotics are useful in helping to eradicate SIBO.

clinicaltrials.gov/ct2/show...

ncbi.nlm.nih.gov/pubmed/287...

ncbi.nlm.nih.gov/pubmed/282...

Art